Abstract
Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.
| Original language | English |
|---|---|
| Pages (from-to) | 172-178 |
| Number of pages | 7 |
| Journal | Journal of Bone and Mineral Metabolism |
| Volume | 21 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2003 |
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Keywords
- Acute lymphoblastic leukemia
- Gonadal dysfunction
- Linear growth
ASJC Scopus subject areas
- Endocrinology
Cite this
Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia. / Yamashita, Nobuko; Tanaka, Hiroyuki; Moriwake, Tadashi; Nishiuchi, Ritsuo; Oda, Megumi; Seino, Yoshiki.
In: Journal of Bone and Mineral Metabolism, Vol. 21, No. 3, 2003, p. 172-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia
AU - Yamashita, Nobuko
AU - Tanaka, Hiroyuki
AU - Moriwake, Tadashi
AU - Nishiuchi, Ritsuo
AU - Oda, Megumi
AU - Seino, Yoshiki
PY - 2003
Y1 - 2003
N2 - Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.
AB - Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.
KW - Acute lymphoblastic leukemia
KW - Gonadal dysfunction
KW - Linear growth
UR - http://www.scopus.com/inward/record.url?scp=0642275549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0642275549&partnerID=8YFLogxK
U2 - 10.1007/s007740300027
DO - 10.1007/s007740300027
M3 - Article
C2 - 12720052
AN - SCOPUS:0642275549
VL - 21
SP - 172
EP - 178
JO - Journal of Bone and Mineral Metabolism
JF - Journal of Bone and Mineral Metabolism
SN - 0914-8779
IS - 3
ER -