Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia

Nobuko Yamashita, Hiroyuki Tanaka, Tadashi Moriwake, Ritsuo Nishiuchi, Megumi Oda, Yoshiki Seino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalJournal of Bone and Mineral Metabolism
Volume21
Issue number3
DOIs
Publication statusPublished - 2003

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survivors
Growth
Therapeutics
Cranial Irradiation
Puberty
Individuality
Bone Density
Creatinine
Quality of Life
Drug Therapy

Keywords

  • Acute lymphoblastic leukemia
  • Gonadal dysfunction
  • Linear growth

ASJC Scopus subject areas

  • Endocrinology

Cite this

Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia. / Yamashita, Nobuko; Tanaka, Hiroyuki; Moriwake, Tadashi; Nishiuchi, Ritsuo; Oda, Megumi; Seino, Yoshiki.

In: Journal of Bone and Mineral Metabolism, Vol. 21, No. 3, 2003, p. 172-178.

Research output: Contribution to journalArticle

Yamashita, Nobuko ; Tanaka, Hiroyuki ; Moriwake, Tadashi ; Nishiuchi, Ritsuo ; Oda, Megumi ; Seino, Yoshiki. / Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia. In: Journal of Bone and Mineral Metabolism. 2003 ; Vol. 21, No. 3. pp. 172-178.
@article{fcaaafb3e5c242bb840ac79a85f5f7c7,
title = "Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia",
abstract = "Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.",
keywords = "Acute lymphoblastic leukemia, Gonadal dysfunction, Linear growth",
author = "Nobuko Yamashita and Hiroyuki Tanaka and Tadashi Moriwake and Ritsuo Nishiuchi and Megumi Oda and Yoshiki Seino",
year = "2003",
doi = "10.1007/s007740300027",
language = "English",
volume = "21",
pages = "172--178",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia

AU - Yamashita, Nobuko

AU - Tanaka, Hiroyuki

AU - Moriwake, Tadashi

AU - Nishiuchi, Ritsuo

AU - Oda, Megumi

AU - Seino, Yoshiki

PY - 2003

Y1 - 2003

N2 - Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.

AB - Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.

KW - Acute lymphoblastic leukemia

KW - Gonadal dysfunction

KW - Linear growth

UR - http://www.scopus.com/inward/record.url?scp=0642275549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0642275549&partnerID=8YFLogxK

U2 - 10.1007/s007740300027

DO - 10.1007/s007740300027

M3 - Article

VL - 21

SP - 172

EP - 178

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 3

ER -