Analysis of linear growth in survivors of childhood acute lymphoblastic leukemia

Nobuko Yamashita, Hiroyuki Tanaka, Tadashi Moriwake, Ritsuo Nishiuchi, Megumi Oda, Yoshiki Seino

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Therapy for childhood acute lymphoblastic leukemia (ALL) is entering a new era in terms of quality-of-life. In the current study, 21 patients with childhood-onset ALL were assessed for linear growth, bone mineral density (BMD), and endocrinological status, focusing especially on longitudinal analysis of the growth of each patient. Linear growth was uniformly attenuated during therapy in all patients. In contrast, after the cessation of therapy, the growth of each patient varied widely from attenuated to dramatic catch-up growth. In pubertal survivors who had received chemotherapy and cranial irradiation during prepuberty, the degree of growth after the cessation of therapy was negatively correlated with changes in height Z scores during therapy (r = -0.76, P = 0.004). One of the factors involved in catch-up growth, urinary N-telopeptide/creatinine (U-NTx/Cr), was significantly higher in patients whose Z scores decreased after cessation of therapy (P = 0.01), despite normal pubertal development and normal endocrinological assessments. The present study revealed individual differences in linear growth after the cessation of therapy and suggests the importance of catch-up growth during puberty.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalJournal of Bone and Mineral Metabolism
Issue number3
Publication statusPublished - 2003
Externally publishedYes


  • Acute lymphoblastic leukemia
  • Gonadal dysfunction
  • Linear growth

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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