Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer

Mizuki Onozawa, Naoto Miyanaga, Shiro Hinotsu, Jun Miyazaki, Takehiro Oikawa, Tomokazu Kimura, Ei Ichiro Takaoka, Koji Kawai, Toru Shimazui, Hideyuki Sakurai, Hiroyuki Nishiyama, Hideyuki Akaza

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: The aim of the present study was to analyze the pattern of recurrences after bladder-preserving therapy for muscle-invasive bladder cancer. Methods: The subjects were 77 patients with T2-3N0M0 bladder cancer whose bladder was preserved by intra-arterial chemotherapy and radiation. The patterns of the first recurrences were retrospectively analyzed. Results: With a median follow-up of 38.5 months, 17 patients (22.1%) experienced intravesical recurrence without metastasis, 14 (82.4%) of which were cases of non-muscle-invasive bladder cancer recurrence and 3 (17.6%) of which were muscle-invasive bladder cancer recurrences. Muscle-invasive bladder cancer recurred at the same site as the initial tumor site in all three cases, whereas non-muscle-invasive bladder cancer recurred at different sites in 64% of the patients in that group. The peak hazard of the non-muscle-invasive bladder cancer recurrence was observed at around a year after treatment. Recurrent non-muscle-invasive bladder cancer was of a significantly lower histological grade with lower Ki-67-labeling indices than the initial muscle-invasive bladder cancer. Twelve (85.7%) of 14 patients with non-muscle-invasive bladder cancer recurrence achieved disease-free status. The multivariate analysis revealed that multiplicity, grade and tumor size were significantly correlated with the recurrence (P = 0.0001, 0.0442 and 0.0412, respectively). Conclusions: Most of the recurrences after bladder-preserving therapy were cases of non-muscle-invasive bladder cancer. The recurrence pattern and characteristics of the tumors did not differ from those of primary non-muscle-invasive bladder cancer. Patients with high-risk factors would be candidates for prophylactic intravesical therapy for non-muscle-invasive bladder cancer recurrence.

Original languageEnglish
Article numberhys105
Pages (from-to)825-830
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume42
Issue number9
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Urinary Bladder
Recurrence
Muscles
Therapeutics
Neoplasms
Multivariate Analysis
Radiation
Neoplasm Metastasis

Keywords

  • Drug therapy
  • Preservation
  • Radiation
  • Recurrence
  • Urinary bladder neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Onozawa, M., Miyanaga, N., Hinotsu, S., Miyazaki, J., Oikawa, T., Kimura, T., ... Akaza, H. (2012). Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer. Japanese Journal of Clinical Oncology, 42(9), 825-830. [hys105]. https://doi.org/10.1093/jjco/hys105

Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer. / Onozawa, Mizuki; Miyanaga, Naoto; Hinotsu, Shiro; Miyazaki, Jun; Oikawa, Takehiro; Kimura, Tomokazu; Takaoka, Ei Ichiro; Kawai, Koji; Shimazui, Toru; Sakurai, Hideyuki; Nishiyama, Hiroyuki; Akaza, Hideyuki.

In: Japanese Journal of Clinical Oncology, Vol. 42, No. 9, hys105, 09.2012, p. 825-830.

Research output: Contribution to journalArticle

Onozawa, M, Miyanaga, N, Hinotsu, S, Miyazaki, J, Oikawa, T, Kimura, T, Takaoka, EI, Kawai, K, Shimazui, T, Sakurai, H, Nishiyama, H & Akaza, H 2012, 'Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer', Japanese Journal of Clinical Oncology, vol. 42, no. 9, hys105, pp. 825-830. https://doi.org/10.1093/jjco/hys105
Onozawa, Mizuki ; Miyanaga, Naoto ; Hinotsu, Shiro ; Miyazaki, Jun ; Oikawa, Takehiro ; Kimura, Tomokazu ; Takaoka, Ei Ichiro ; Kawai, Koji ; Shimazui, Toru ; Sakurai, Hideyuki ; Nishiyama, Hiroyuki ; Akaza, Hideyuki. / Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer. In: Japanese Journal of Clinical Oncology. 2012 ; Vol. 42, No. 9. pp. 825-830.
@article{6f8b4146cec842fc98479d24f6c6e988,
title = "Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer",
abstract = "Objective: The aim of the present study was to analyze the pattern of recurrences after bladder-preserving therapy for muscle-invasive bladder cancer. Methods: The subjects were 77 patients with T2-3N0M0 bladder cancer whose bladder was preserved by intra-arterial chemotherapy and radiation. The patterns of the first recurrences were retrospectively analyzed. Results: With a median follow-up of 38.5 months, 17 patients (22.1{\%}) experienced intravesical recurrence without metastasis, 14 (82.4{\%}) of which were cases of non-muscle-invasive bladder cancer recurrence and 3 (17.6{\%}) of which were muscle-invasive bladder cancer recurrences. Muscle-invasive bladder cancer recurred at the same site as the initial tumor site in all three cases, whereas non-muscle-invasive bladder cancer recurred at different sites in 64{\%} of the patients in that group. The peak hazard of the non-muscle-invasive bladder cancer recurrence was observed at around a year after treatment. Recurrent non-muscle-invasive bladder cancer was of a significantly lower histological grade with lower Ki-67-labeling indices than the initial muscle-invasive bladder cancer. Twelve (85.7{\%}) of 14 patients with non-muscle-invasive bladder cancer recurrence achieved disease-free status. The multivariate analysis revealed that multiplicity, grade and tumor size were significantly correlated with the recurrence (P = 0.0001, 0.0442 and 0.0412, respectively). Conclusions: Most of the recurrences after bladder-preserving therapy were cases of non-muscle-invasive bladder cancer. The recurrence pattern and characteristics of the tumors did not differ from those of primary non-muscle-invasive bladder cancer. Patients with high-risk factors would be candidates for prophylactic intravesical therapy for non-muscle-invasive bladder cancer recurrence.",
keywords = "Drug therapy, Preservation, Radiation, Recurrence, Urinary bladder neoplasms",
author = "Mizuki Onozawa and Naoto Miyanaga and Shiro Hinotsu and Jun Miyazaki and Takehiro Oikawa and Tomokazu Kimura and Takaoka, {Ei Ichiro} and Koji Kawai and Toru Shimazui and Hideyuki Sakurai and Hiroyuki Nishiyama and Hideyuki Akaza",
year = "2012",
month = "9",
doi = "10.1093/jjco/hys105",
language = "English",
volume = "42",
pages = "825--830",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Analysis of intravesical recurrence after bladder-preserving therapy for muscle-invasive bladder cancer

AU - Onozawa, Mizuki

AU - Miyanaga, Naoto

AU - Hinotsu, Shiro

AU - Miyazaki, Jun

AU - Oikawa, Takehiro

AU - Kimura, Tomokazu

AU - Takaoka, Ei Ichiro

AU - Kawai, Koji

AU - Shimazui, Toru

AU - Sakurai, Hideyuki

AU - Nishiyama, Hiroyuki

AU - Akaza, Hideyuki

PY - 2012/9

Y1 - 2012/9

N2 - Objective: The aim of the present study was to analyze the pattern of recurrences after bladder-preserving therapy for muscle-invasive bladder cancer. Methods: The subjects were 77 patients with T2-3N0M0 bladder cancer whose bladder was preserved by intra-arterial chemotherapy and radiation. The patterns of the first recurrences were retrospectively analyzed. Results: With a median follow-up of 38.5 months, 17 patients (22.1%) experienced intravesical recurrence without metastasis, 14 (82.4%) of which were cases of non-muscle-invasive bladder cancer recurrence and 3 (17.6%) of which were muscle-invasive bladder cancer recurrences. Muscle-invasive bladder cancer recurred at the same site as the initial tumor site in all three cases, whereas non-muscle-invasive bladder cancer recurred at different sites in 64% of the patients in that group. The peak hazard of the non-muscle-invasive bladder cancer recurrence was observed at around a year after treatment. Recurrent non-muscle-invasive bladder cancer was of a significantly lower histological grade with lower Ki-67-labeling indices than the initial muscle-invasive bladder cancer. Twelve (85.7%) of 14 patients with non-muscle-invasive bladder cancer recurrence achieved disease-free status. The multivariate analysis revealed that multiplicity, grade and tumor size were significantly correlated with the recurrence (P = 0.0001, 0.0442 and 0.0412, respectively). Conclusions: Most of the recurrences after bladder-preserving therapy were cases of non-muscle-invasive bladder cancer. The recurrence pattern and characteristics of the tumors did not differ from those of primary non-muscle-invasive bladder cancer. Patients with high-risk factors would be candidates for prophylactic intravesical therapy for non-muscle-invasive bladder cancer recurrence.

AB - Objective: The aim of the present study was to analyze the pattern of recurrences after bladder-preserving therapy for muscle-invasive bladder cancer. Methods: The subjects were 77 patients with T2-3N0M0 bladder cancer whose bladder was preserved by intra-arterial chemotherapy and radiation. The patterns of the first recurrences were retrospectively analyzed. Results: With a median follow-up of 38.5 months, 17 patients (22.1%) experienced intravesical recurrence without metastasis, 14 (82.4%) of which were cases of non-muscle-invasive bladder cancer recurrence and 3 (17.6%) of which were muscle-invasive bladder cancer recurrences. Muscle-invasive bladder cancer recurred at the same site as the initial tumor site in all three cases, whereas non-muscle-invasive bladder cancer recurred at different sites in 64% of the patients in that group. The peak hazard of the non-muscle-invasive bladder cancer recurrence was observed at around a year after treatment. Recurrent non-muscle-invasive bladder cancer was of a significantly lower histological grade with lower Ki-67-labeling indices than the initial muscle-invasive bladder cancer. Twelve (85.7%) of 14 patients with non-muscle-invasive bladder cancer recurrence achieved disease-free status. The multivariate analysis revealed that multiplicity, grade and tumor size were significantly correlated with the recurrence (P = 0.0001, 0.0442 and 0.0412, respectively). Conclusions: Most of the recurrences after bladder-preserving therapy were cases of non-muscle-invasive bladder cancer. The recurrence pattern and characteristics of the tumors did not differ from those of primary non-muscle-invasive bladder cancer. Patients with high-risk factors would be candidates for prophylactic intravesical therapy for non-muscle-invasive bladder cancer recurrence.

KW - Drug therapy

KW - Preservation

KW - Radiation

KW - Recurrence

KW - Urinary bladder neoplasms

UR - http://www.scopus.com/inward/record.url?scp=84865552004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865552004&partnerID=8YFLogxK

U2 - 10.1093/jjco/hys105

DO - 10.1093/jjco/hys105

M3 - Article

C2 - 22782963

AN - SCOPUS:84865552004

VL - 42

SP - 825

EP - 830

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 9

M1 - hys105

ER -