TY - JOUR
T1 - Analysis of inflammatory cytokines and estimated glomerular filtration rate decline in Japanese patients with diabetic kidney disease
T2 - a pilot study
AU - Sugawara, Yuka
AU - Hirakawa, Yosuke
AU - Mise, Koki
AU - Kashiwabara, Kosuke
AU - Hanai, Ko
AU - Yamaguchi, Satoshi
AU - Katayama, Akihiro
AU - Onishi, Yasuhiro
AU - Yoshida, Yui
AU - Kashihara, Naoki
AU - Matsuyama, Yutaka
AU - Babazono, Tetsuya
AU - Nangaku, Masaomi
AU - Wada, Jun
N1 - Funding Information:
Y Hirakawa, Y Yoshida, N Kashihara, M Nangaku and J Wada conceptualized the study. Y Sugawara was responsible for the measurement of cytokines. Y Sugawara and Y Hirakawa wrote the original draft. K Mise, S Yamaguchi, A Katayama, Y Onishi and J Wada were responsible for the data curation and the collection of plasma samples in the U-CARE cohort. K Hanai and T Babazono were responsible for the data curation and the collection of serum samples in the TWMU cohort. K Kashiwabara and Y Matsuyama were responsible for formal analysis. N Kashihara was responsible for funding acquisition. J Wada, T Babazono, M Nangaku and K Kashihara provided supervision. All the authors reviewed and edited the manuscript.
Publisher Copyright:
© 2022 Future Medicine Ltd.
PY - 2022/7
Y1 - 2022/7
N2 - Background: It is important to identify additional prognostic factors for diabetic kidney disease. Materials & methods: Baseline levels of ten cytokines (APRIL/TNFSF13, BAFF/TNFSF13B, chitinase 3-like 1, LIGHT/TNFSF14, TWEAK/TNFSF12, gp130/sIL-6Rβ, sCD163, sIL-6Rα, sTNF-R1, sTNF-R2) were measured in two cohorts of diabetic patients. In one cohort (n = 777), 156 individuals were randomly sampled after stratification and their plasma samples were analyzed; in the other cohort (n = 69), serum samples were analyzed in all the individuals. The levels of cytokines between rapid (estimated glomerular filtration rate decline >5 ml/min/1.73 m2/year) and non-rapid decliners were compared. Results: Multivariate analysis demonstrated significantly high levels of LIGHT/TNFSF14, TWEAK/TNFSF12 and sTNF-R2 in rapid decliners. Conclusion: These three cytokines can be potential biomarkers for the progression of diabetic kidney disease.
AB - Background: It is important to identify additional prognostic factors for diabetic kidney disease. Materials & methods: Baseline levels of ten cytokines (APRIL/TNFSF13, BAFF/TNFSF13B, chitinase 3-like 1, LIGHT/TNFSF14, TWEAK/TNFSF12, gp130/sIL-6Rβ, sCD163, sIL-6Rα, sTNF-R1, sTNF-R2) were measured in two cohorts of diabetic patients. In one cohort (n = 777), 156 individuals were randomly sampled after stratification and their plasma samples were analyzed; in the other cohort (n = 69), serum samples were analyzed in all the individuals. The levels of cytokines between rapid (estimated glomerular filtration rate decline >5 ml/min/1.73 m2/year) and non-rapid decliners were compared. Results: Multivariate analysis demonstrated significantly high levels of LIGHT/TNFSF14, TWEAK/TNFSF12 and sTNF-R2 in rapid decliners. Conclusion: These three cytokines can be potential biomarkers for the progression of diabetic kidney disease.
KW - biomarkers
KW - cytokines
KW - diabetic kidney disease
KW - glomerular filtration rate
KW - prognosis
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U2 - 10.2217/bmm-2021-1104
DO - 10.2217/bmm-2021-1104
M3 - Article
C2 - 35583042
AN - SCOPUS:85133808212
SN - 1752-0363
VL - 16
SP - 759
EP - 770
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
IS - 10
ER -
