TY - JOUR
T1 - Analysis of human leukocyte antigen genotypes in pemphigus with antidesmoglein antibody profile shift
AU - Mitsui, Seiko
AU - Kamiya, Koji
AU - Tokura, Yoshiki
AU - Iwatsuki, Keiji
AU - Aoyama, Yumi
N1 - Funding Information:
This work was supported by a grant from the Ministry of Health, Labour and Welfare (Research for Intractable Diseases) , and a Ministry of Education, Culture, Sports, Science and Technology . SM and KK contributed equally to this work. We would like to gratefully and sincerely thank Dr. Tomoko Miyake, Dr. Mariko Kawata, Dr. Tetsuya Takiguchi, Dr. Mari Yamaguchi, and Dr. Yoshio Kawakami for their assistance.
Publisher Copyright:
© 2016
PY - 2016/12/1
Y1 - 2016/12/1
N2 - In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift.
AB - In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift.
KW - antidesmoglein 1 antibody
KW - antidesmoglein 3 antibody
KW - human leukocyte antigen
KW - pemphigus foliaceus
KW - pemphigus vulgaris
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U2 - 10.1016/j.dsi.2016.04.001
DO - 10.1016/j.dsi.2016.04.001
M3 - Article
AN - SCOPUS:84994890038
SN - 1027-8117
VL - 34
SP - 205
EP - 208
JO - Dermatologica Sinica
JF - Dermatologica Sinica
IS - 4
ER -