Analysis of human leukocyte antigen genotypes in pemphigus with antidesmoglein antibody profile shift

Seiko Mitsui, Koji Kamiya, Yoshiki Tokura, Keiji Iwatsuki, Yumi Aoyama

Research output: Contribution to journalArticle

Abstract

In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalDermatologica Sinica
Volume34
Issue number4
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • antidesmoglein 1 antibody
  • antidesmoglein 3 antibody
  • human leukocyte antigen
  • pemphigus foliaceus
  • pemphigus vulgaris

ASJC Scopus subject areas

  • Dermatology

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