Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery

Y. Kanaoka, Takahito Yagi, H. Sadamori, H. Matsukawa, H. Matsuda, M. Inagaki, I. Ishikawa, Shinya Saito, H. Iwagaki, N. Tanaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We analysed the host response to hepatectomy by simultaneous measurement of various cytokines and their antagonists in the portal vein, caval vein and radial artery in 10 patients with hepatocellular carcinoma. Concentrations of tumour necrosis factor-α (TNF), interleukin (IL) 1β, IL-2, IL,10, soluble TNF receptor type I (sTNF-R), soluble IL-2 receptor (sIL-2R), IL-1 receptor antagonist (IL-1ra), soluble CD14 (sCD14) and endotoxin were determined just before and 1 h after hepatectomy. The values of IL-6, sTNR-R and IL-1ra were significantly increased after hepatectomy at each sampling site. In contrast, the levels of sIL-2R and sCD14 after hepatectomy were significantly decreased, and the levels of IL-1β, IL-2 and IL-10 were below the detection limits. Differences in cytokine concentrations between sampling sites revealed that the surgical stress of hepatectomy induced significant IL-1ra production in the liver and sTNF-R and IL-6 production in the lungs. These results suggest that hepatic resection is followed by the production of cytokine antagonists, such as IL-1ra, sTNF-R and IL-6, which could represent an important regulatory mechanism against surgical stress.

Original languageEnglish
Pages (from-to)496-505
Number of pages10
JournalJournal of International Medical Research
Volume30
Issue number5
Publication statusPublished - Sep 2002

Fingerprint

Venae Cavae
Radial Artery
Interleukins
Hepatectomy
Portal Vein
Veins
Interleukin-6
Interleukin-2 Receptors
Cytokines
Interleukin-1
Interleukin-10
Interleukin-2
Receptors, Tumor Necrosis Factor, Type I
Sampling
Interleukin-1 Receptors
Endotoxins
Liver
Tumor Necrosis Factor-alpha
Limit of Detection
Hepatocellular Carcinoma

Keywords

  • Cytokine antagonists
  • Cytokines
  • Hepatectomy
  • Surgical stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery. / Kanaoka, Y.; Yagi, Takahito; Sadamori, H.; Matsukawa, H.; Matsuda, H.; Inagaki, M.; Ishikawa, I.; Saito, Shinya; Iwagaki, H.; Tanaka, N.

In: Journal of International Medical Research, Vol. 30, No. 5, 09.2002, p. 496-505.

Research output: Contribution to journalArticle

Kanaoka, Y, Yagi, T, Sadamori, H, Matsukawa, H, Matsuda, H, Inagaki, M, Ishikawa, I, Saito, S, Iwagaki, H & Tanaka, N 2002, 'Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery', Journal of International Medical Research, vol. 30, no. 5, pp. 496-505.
Kanaoka, Y. ; Yagi, Takahito ; Sadamori, H. ; Matsukawa, H. ; Matsuda, H. ; Inagaki, M. ; Ishikawa, I. ; Saito, Shinya ; Iwagaki, H. ; Tanaka, N. / Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery. In: Journal of International Medical Research. 2002 ; Vol. 30, No. 5. pp. 496-505.
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