Analysis of host response to hepatectomy by simultaneous measurement of cytokines in the portal vein, caval vein and radial artery

Y. Kanaoka, T. Yagi, H. Sadamori, H. Matsukawa, H. Matsuda, M. Inagaki, I. Ishikawa, S. Saito, H. Iwagaki, N. Tanaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We analysed the host response to hepatectomy by simultaneous measurement of various cytokines and their antagonists in the portal vein, caval vein and radial artery in 10 patients with hepatocellular carcinoma. Concentrations of tumour necrosis factor-α (TNF), interleukin (IL) 1β, IL-2, IL,10, soluble TNF receptor type I (sTNF-R), soluble IL-2 receptor (sIL-2R), IL-1 receptor antagonist (IL-1ra), soluble CD14 (sCD14) and endotoxin were determined just before and 1 h after hepatectomy. The values of IL-6, sTNR-R and IL-1ra were significantly increased after hepatectomy at each sampling site. In contrast, the levels of sIL-2R and sCD14 after hepatectomy were significantly decreased, and the levels of IL-1β, IL-2 and IL-10 were below the detection limits. Differences in cytokine concentrations between sampling sites revealed that the surgical stress of hepatectomy induced significant IL-1ra production in the liver and sTNF-R and IL-6 production in the lungs. These results suggest that hepatic resection is followed by the production of cytokine antagonists, such as IL-1ra, sTNF-R and IL-6, which could represent an important regulatory mechanism against surgical stress.

Original languageEnglish
Pages (from-to)496-505
Number of pages10
JournalJournal of International Medical Research
Volume30
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Cytokine antagonists
  • Cytokines
  • Hepatectomy
  • Surgical stress

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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