Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease

Tooru Araki, Aya Kodera, Kunimi Kitada, Michimasa Fujiwara, Michiko Muraoka, Yoshiko Abe, Masanori Ikeda, Hirokazu Tsukahara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD). Methods: Among patients who had received BCG vaccination and treatment for KD at our hospital from 2005 through 2016, 177 patients born in 2005 through 2016 were enrolled. The patients were divided into those with (n = 83, change group) and without (n = 94, no-change group) a BCG site change, and the patient demographics, clinical severity, blood examination results, and echocardiographic findings were compared between the two groups. Results: The change group was younger at onset and had a shorter interval from vaccination to onset. A BCG site change was observed in patients who developed the onset of KD symptoms from 31 to 806 days after BCG vaccination. Multivariate analysis showed that the interval from vaccination was closely and positively associated with the BCG site change (hazard ratio = 0.995, 95% confidence interval = 0.993–0.997). Conclusion: A BCG site change in patients with KD is most closely associated with the interval from BCG vaccination to onset.

Original languageEnglish
Pages (from-to)1640-1648
Number of pages9
JournalJournal of International Medical Research
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

Keywords

  • Bacille Calmette–Guérin
  • Japan
  • Kawasaki disease
  • infant
  • inoculation site change
  • risk factors

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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