Abstract
Objective: The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD). Methods: Among patients who had received BCG vaccination and treatment for KD at our hospital from 2005 through 2016, 177 patients born in 2005 through 2016 were enrolled. The patients were divided into those with (n = 83, change group) and without (n = 94, no-change group) a BCG site change, and the patient demographics, clinical severity, blood examination results, and echocardiographic findings were compared between the two groups. Results: The change group was younger at onset and had a shorter interval from vaccination to onset. A BCG site change was observed in patients who developed the onset of KD symptoms from 31 to 806 days after BCG vaccination. Multivariate analysis showed that the interval from vaccination was closely and positively associated with the BCG site change (hazard ratio = 0.995, 95% confidence interval = 0.993–0.997). Conclusion: A BCG site change in patients with KD is most closely associated with the interval from BCG vaccination to onset.
| Original language | English |
|---|---|
| Pages (from-to) | 1640-1648 |
| Number of pages | 9 |
| Journal | Journal of International Medical Research |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2018 |
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Keywords
- Bacille Calmette–Guérin
- infant
- inoculation site change
- Japan
- Kawasaki disease
- risk factors
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Biochemistry, medical
Cite this
Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease. / Araki, Tooru; Kodera, Aya; Kitada, Kunimi; Fujiwara, Michimasa; Muraoka, Michiko; Abe, Yoshiko; Ikeda, Masanori; Tsukahara, Hirokazu.
In: Journal of International Medical Research, Vol. 46, No. 4, 01.04.2018, p. 1640-1648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease
AU - Araki, Tooru
AU - Kodera, Aya
AU - Kitada, Kunimi
AU - Fujiwara, Michimasa
AU - Muraoka, Michiko
AU - Abe, Yoshiko
AU - Ikeda, Masanori
AU - Tsukahara, Hirokazu
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objective: The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD). Methods: Among patients who had received BCG vaccination and treatment for KD at our hospital from 2005 through 2016, 177 patients born in 2005 through 2016 were enrolled. The patients were divided into those with (n = 83, change group) and without (n = 94, no-change group) a BCG site change, and the patient demographics, clinical severity, blood examination results, and echocardiographic findings were compared between the two groups. Results: The change group was younger at onset and had a shorter interval from vaccination to onset. A BCG site change was observed in patients who developed the onset of KD symptoms from 31 to 806 days after BCG vaccination. Multivariate analysis showed that the interval from vaccination was closely and positively associated with the BCG site change (hazard ratio = 0.995, 95% confidence interval = 0.993–0.997). Conclusion: A BCG site change in patients with KD is most closely associated with the interval from BCG vaccination to onset.
AB - Objective: The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD). Methods: Among patients who had received BCG vaccination and treatment for KD at our hospital from 2005 through 2016, 177 patients born in 2005 through 2016 were enrolled. The patients were divided into those with (n = 83, change group) and without (n = 94, no-change group) a BCG site change, and the patient demographics, clinical severity, blood examination results, and echocardiographic findings were compared between the two groups. Results: The change group was younger at onset and had a shorter interval from vaccination to onset. A BCG site change was observed in patients who developed the onset of KD symptoms from 31 to 806 days after BCG vaccination. Multivariate analysis showed that the interval from vaccination was closely and positively associated with the BCG site change (hazard ratio = 0.995, 95% confidence interval = 0.993–0.997). Conclusion: A BCG site change in patients with KD is most closely associated with the interval from BCG vaccination to onset.
KW - Bacille Calmette–Guérin
KW - infant
KW - inoculation site change
KW - Japan
KW - Kawasaki disease
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85044827516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044827516&partnerID=8YFLogxK
U2 - 10.1177/0300060518760462
DO - 10.1177/0300060518760462
M3 - Article
VL - 46
SP - 1640
EP - 1648
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 4
ER -