Analysis of DNA damage generated by high-energy particles.

Hiroaki Terato; Ruri Tanaka; Yusuke Nakaarai; Yoshiya Furusawa; Hiroshi Ide

Analysis of DNA damage generated by high-energy particles.

Hiroaki Terato, Ruri Tanaka, Yusuke Nakaarai, Yoshiya Furusawa, Hiroshi Ide

Research output: Contribution to journal › Article › peer-review

Abstract

Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.

Original language	English
Pages (from-to)	145-146
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	48
Publication status	Published - 2004
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Analysis of DNA damage generated by high-energy particles.",

abstract = "Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.",

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year = "2004",

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AU - Terato, Hiroaki

AU - Tanaka, Ruri

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AU - Ide, Hiroshi

PY - 2004

Y1 - 2004

N2 - Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.

AB - Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.

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Analysis of DNA damage generated by high-energy particles.

Abstract

ASJC Scopus subject areas

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