Abstract
We have successfully measured the complex permittivity of liposome as very important biochemical species, dependent on frequency up to 30 GHz (millimeter-wave range), for the first time, by an open-ended coaxial probe method improved for measuring a very small amount of liquid solution. We used a probe size as small as 1.2 mmφ, which leads to upper frequency limit usable of 90 GHz. Also found that the method is very suitable for evaluation of series of biochemical solution with a small amount (1-2 ml) in a short period. It is revealed, as a result of membrane dynamics of liposome, that l)temperature dependency of relaxation time of DPPC liposome in dispersion regions(0.2-30 GHz), is attributed to bulk water, cation and anion, 2)increase in the relaxation time results from dynamics of trapping/bounding of water by cation and anion, and 3)cholesterol addition to liposome gives a new dispersion(around 1 GHz), possible to relate to water molecules that freely move in/on the liposome surface. We think the method is a promising tool for exploring basic biochemistry of liposome and related solution systems.
| Original language | English |
|---|---|
| Title of host publication | IEEE MTT-S International Microwave Symposium Digest |
| Pages | 1983-1986 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
| Event | 2006 IEEE MTT-S International Microwave Symposium Digest - San Francisco, CA, United States Duration: Jun 11 2006 → Jun 16 2006 |
Other
| Other | 2006 IEEE MTT-S International Microwave Symposium Digest |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 6/11/06 → 6/16/06 |
Fingerprint
Keywords
- Biochemistry
- Biomolecular electronics
- Coaxial components
- Dielectric losses
- Dynamic response
- Permittivity
- Relaxation processes
ASJC Scopus subject areas
- Condensed Matter Physics
- Electrical and Electronic Engineering
Cite this
Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range. / Noda, Minoru; Shimanouchi, Toshinori; Suzuki, Hirosuke; Okuyama, Masanori; Kuboi, Ryouichi.
IEEE MTT-S International Microwave Symposium Digest. 2006. p. 1983-1986 4015349.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range
AU - Noda, Minoru
AU - Shimanouchi, Toshinori
AU - Suzuki, Hirosuke
AU - Okuyama, Masanori
AU - Kuboi, Ryouichi
PY - 2006
Y1 - 2006
N2 - We have successfully measured the complex permittivity of liposome as very important biochemical species, dependent on frequency up to 30 GHz (millimeter-wave range), for the first time, by an open-ended coaxial probe method improved for measuring a very small amount of liquid solution. We used a probe size as small as 1.2 mmφ, which leads to upper frequency limit usable of 90 GHz. Also found that the method is very suitable for evaluation of series of biochemical solution with a small amount (1-2 ml) in a short period. It is revealed, as a result of membrane dynamics of liposome, that l)temperature dependency of relaxation time of DPPC liposome in dispersion regions(0.2-30 GHz), is attributed to bulk water, cation and anion, 2)increase in the relaxation time results from dynamics of trapping/bounding of water by cation and anion, and 3)cholesterol addition to liposome gives a new dispersion(around 1 GHz), possible to relate to water molecules that freely move in/on the liposome surface. We think the method is a promising tool for exploring basic biochemistry of liposome and related solution systems.
AB - We have successfully measured the complex permittivity of liposome as very important biochemical species, dependent on frequency up to 30 GHz (millimeter-wave range), for the first time, by an open-ended coaxial probe method improved for measuring a very small amount of liquid solution. We used a probe size as small as 1.2 mmφ, which leads to upper frequency limit usable of 90 GHz. Also found that the method is very suitable for evaluation of series of biochemical solution with a small amount (1-2 ml) in a short period. It is revealed, as a result of membrane dynamics of liposome, that l)temperature dependency of relaxation time of DPPC liposome in dispersion regions(0.2-30 GHz), is attributed to bulk water, cation and anion, 2)increase in the relaxation time results from dynamics of trapping/bounding of water by cation and anion, and 3)cholesterol addition to liposome gives a new dispersion(around 1 GHz), possible to relate to water molecules that freely move in/on the liposome surface. We think the method is a promising tool for exploring basic biochemistry of liposome and related solution systems.
KW - Biochemistry
KW - Biomolecular electronics
KW - Coaxial components
KW - Dielectric losses
KW - Dynamic response
KW - Permittivity
KW - Relaxation processes
UR - http://www.scopus.com/inward/record.url?scp=34250330000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250330000&partnerID=8YFLogxK
U2 - 10.1109/MWSYM.2006.249824
DO - 10.1109/MWSYM.2006.249824
M3 - Conference contribution
AN - SCOPUS:34250330000
SP - 1983
EP - 1986
BT - IEEE MTT-S International Microwave Symposium Digest
ER -