Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range

Minoru Noda, Toshinori Shimanouchi, Hirosuke Suzuki, Masanori Okuyama, Ryouichi Kuboi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Abstract

We have successfully measured the complex permittivity of liposome as very important biochemical species, dependent on frequency up to 30 GHz (millimeter-wave range), for the first time, by an open-ended coaxial probe method improved for measuring a very small amount of liquid solution. We used a probe size as small as 1.2 mmφ, which leads to upper frequency limit usable of 90 GHz. Also found that the method is very suitable for evaluation of series of biochemical solution with a small amount (1-2 ml) in a short period. It is revealed, as a result of membrane dynamics of liposome, that l)temperature dependency of relaxation time of DPPC liposome in dispersion regions(0.2-30 GHz), is attributed to bulk water, cation and anion, 2)increase in the relaxation time results from dynamics of trapping/bounding of water by cation and anion, and 3)cholesterol addition to liposome gives a new dispersion(around 1 GHz), possible to relate to water molecules that freely move in/on the liposome surface. We think the method is a promising tool for exploring basic biochemistry of liposome and related solution systems.

Original languageEnglish
Title of host publicationIEEE MTT-S International Microwave Symposium Digest
Pages1983-1986
Number of pages4
DOIs
Publication statusPublished - 2006
Externally publishedYes
Event2006 IEEE MTT-S International Microwave Symposium Digest - San Francisco, CA, United States
Duration: Jun 11 2006Jun 16 2006

Other

Other2006 IEEE MTT-S International Microwave Symposium Digest
CountryUnited States
CitySan Francisco, CA
Period6/11/066/16/06

Fingerprint

Liposomes
Permittivity
permittivity
relaxation time
water
anions
cations
biochemistry
cholesterol
Relaxation time
millimeter waves
Negative ions
Positive ions
trapping
membranes
Water
Biochemistry
evaluation
probes
Cholesterol

Keywords

  • Biochemistry
  • Biomolecular electronics
  • Coaxial components
  • Dielectric losses
  • Dynamic response
  • Permittivity
  • Relaxation processes

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Noda, M., Shimanouchi, T., Suzuki, H., Okuyama, M., & Kuboi, R. (2006). Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range. In IEEE MTT-S International Microwave Symposium Digest (pp. 1983-1986). [4015349] https://doi.org/10.1109/MWSYM.2006.249824

Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range. / Noda, Minoru; Shimanouchi, Toshinori; Suzuki, Hirosuke; Okuyama, Masanori; Kuboi, Ryouichi.

IEEE MTT-S International Microwave Symposium Digest. 2006. p. 1983-1986 4015349.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noda, M, Shimanouchi, T, Suzuki, H, Okuyama, M & Kuboi, R 2006, Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range. in IEEE MTT-S International Microwave Symposium Digest., 4015349, pp. 1983-1986, 2006 IEEE MTT-S International Microwave Symposium Digest, San Francisco, CA, United States, 6/11/06. https://doi.org/10.1109/MWSYM.2006.249824
Noda M, Shimanouchi T, Suzuki H, Okuyama M, Kuboi R. Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range. In IEEE MTT-S International Microwave Symposium Digest. 2006. p. 1983-1986. 4015349 https://doi.org/10.1109/MWSYM.2006.249824
Noda, Minoru ; Shimanouchi, Toshinori ; Suzuki, Hirosuke ; Okuyama, Masanori ; Kuboi, Ryouichi. / Analysis of complex permittivity of liposome for its biochemical dynamics up to 30 GHz range. IEEE MTT-S International Microwave Symposium Digest. 2006. pp. 1983-1986
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AB - We have successfully measured the complex permittivity of liposome as very important biochemical species, dependent on frequency up to 30 GHz (millimeter-wave range), for the first time, by an open-ended coaxial probe method improved for measuring a very small amount of liquid solution. We used a probe size as small as 1.2 mmφ, which leads to upper frequency limit usable of 90 GHz. Also found that the method is very suitable for evaluation of series of biochemical solution with a small amount (1-2 ml) in a short period. It is revealed, as a result of membrane dynamics of liposome, that l)temperature dependency of relaxation time of DPPC liposome in dispersion regions(0.2-30 GHz), is attributed to bulk water, cation and anion, 2)increase in the relaxation time results from dynamics of trapping/bounding of water by cation and anion, and 3)cholesterol addition to liposome gives a new dispersion(around 1 GHz), possible to relate to water molecules that freely move in/on the liposome surface. We think the method is a promising tool for exploring basic biochemistry of liposome and related solution systems.

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