Anabolic utilization of steroid hormones in Helicobacter pylori

Kouichi Hosoda, Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

In this study, we have demonstrated that Helicobacter pylori absorbs a steroid prehormone (pregnenolone) and two androgens (dehydroepiandrosterone and epiandrosterone), glucosylates these steroids, and utilizes glucosyl-steroid hormone compounds as the membrane lipid components. The only common structure among the steroid prehormone and the two androgens is a 3β-OH in the steroid framework. Our results indicate that the 3β-OH in the steroid hormones is a crucial conformation required for steroid glucosylation by H. pylori. In addition, we found that H. pylori absorbs and holds estrogens possessing 3-OH (estrone and estradiol) into the membrane. The effective absorption of estrogen into the membrane appeared to be controlled by the number of hydroxyl groups modifying the steroid framework. In contrast, H. pylori induced neither membrane absorption nor glucosylation of the other steroid hormones possessing 3=O (progesterone, androstenedione and testosterone) or 3α-OH (androsterone). These results indicate that H. pylori selectively absorbs 3β-OH and 3-OH steroid hormones, and utilizes only 3β-OH steroid hormones as the materials for glucosylation.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalFEMS Microbiology Letters
Volume297
Issue number2
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Glucosylation
  • Helicobacter pylori
  • Steroid hormone

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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