An Ullmann N-arylation/2-amidation cascade by self-relay copper catalysis: One-pot synthesis of indolo[1,2- a] quinazolinones

Takumi Abe, Yuka Takahashi, Yuki Matsubara, Koji Yamada

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

We have developed a self-relay copper(i)-catalyzed Ullmann N-arylation/2-amidation cascade to form functionalized indolo[1,2-a]quinazolinones in one-pot from easily available indoles with 2-bromobenzamides. This novel transformation features a tandem process of Ullmann-type coupling, activation of indolenine, and 2-amidation in the presence of a single copper catalyst. In addition, among the substituents of indoles at the C3 position, methyl carboxylate could act as an activating group in this Ullmann N-arylation/2-amidation cascade.

Original languageEnglish
Pages (from-to)2124-2127
Number of pages4
JournalOrganic Chemistry Frontiers
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 2017
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'An Ullmann N-arylation/2-amidation cascade by self-relay copper catalysis: One-pot synthesis of indolo[1,2- a] quinazolinones'. Together they form a unique fingerprint.

Cite this