An open-label feasibility trial of repetitive transcranial magnetic stimulation for treatment-resistant major depressive episodes

Masaki Fujiwara, Masatoshi Inagaki, Yuji Higuchi, Yosuke Uchitomi, Seishi Terada, Masafumi Kodama, Yoshiki Kishi, Norihito Yamada

Research output: Contribution to journalArticle


Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalActa Medica Okayama
Issue number4
Publication statusPublished - 2016



  • Depression
  • Low frequency
  • Repetitive transcranial magnetic stimulation
  • Treatment resistance

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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