An open-label feasibility trial of repetitive transcranial magnetic stimulation for treatment-resistant major depressive episodes

Masaki Fujiwara, Masatoshi Inagaki, Yuji Higuchi, Yosuke Uchitomi, Seishi Terada, Masafumi Kodama, Yoshiki Kishi, Norihito Yamada

Research output: Contribution to journalArticle

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalActa Medica Okayama
Volume70
Issue number4
Publication statusPublished - 2016

Fingerprint

Transcranial Magnetic Stimulation
Labels
Treatment-Resistant Depressive Disorder
Prefrontal Cortex
Japan
Therapeutics
Major Depressive Disorder
Bipolar Disorder
Outcome Assessment (Health Care)
Research

Keywords

  • Depression
  • Low frequency
  • Repetitive transcranial magnetic stimulation
  • Treatment resistance

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

An open-label feasibility trial of repetitive transcranial magnetic stimulation for treatment-resistant major depressive episodes. / Fujiwara, Masaki; Inagaki, Masatoshi; Higuchi, Yuji; Uchitomi, Yosuke; Terada, Seishi; Kodama, Masafumi; Kishi, Yoshiki; Yamada, Norihito.

In: Acta Medica Okayama, Vol. 70, No. 4, 2016, p. 307-312.

Research output: Contribution to journalArticle

Fujiwara, Masaki ; Inagaki, Masatoshi ; Higuchi, Yuji ; Uchitomi, Yosuke ; Terada, Seishi ; Kodama, Masafumi ; Kishi, Yoshiki ; Yamada, Norihito. / An open-label feasibility trial of repetitive transcranial magnetic stimulation for treatment-resistant major depressive episodes. In: Acta Medica Okayama. 2016 ; Vol. 70, No. 4. pp. 307-312.
@article{8fbc4dc8bfd74a4587e6e9411a51d28c,
title = "An open-label feasibility trial of repetitive transcranial magnetic stimulation for treatment-resistant major depressive episodes",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan.",
keywords = "Depression, Low frequency, Repetitive transcranial magnetic stimulation, Treatment resistance",
author = "Masaki Fujiwara and Masatoshi Inagaki and Yuji Higuchi and Yosuke Uchitomi and Seishi Terada and Masafumi Kodama and Yoshiki Kishi and Norihito Yamada",
year = "2016",
language = "English",
volume = "70",
pages = "307--312",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "4",

}

TY - JOUR

T1 - An open-label feasibility trial of repetitive transcranial magnetic stimulation for treatment-resistant major depressive episodes

AU - Fujiwara, Masaki

AU - Inagaki, Masatoshi

AU - Higuchi, Yuji

AU - Uchitomi, Yosuke

AU - Terada, Seishi

AU - Kodama, Masafumi

AU - Kishi, Yoshiki

AU - Yamada, Norihito

PY - 2016

Y1 - 2016

N2 - Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan.

AB - Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan.

KW - Depression

KW - Low frequency

KW - Repetitive transcranial magnetic stimulation

KW - Treatment resistance

UR - http://www.scopus.com/inward/record.url?scp=84984853548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984853548&partnerID=8YFLogxK

M3 - Article

VL - 70

SP - 307

EP - 312

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 4

ER -