An increased level of specific igg4 antibodies against candida albicans in patients with bronchial asthma

Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fumihiro Mitsunobu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Specific IgG4 antibodies against Candida albicans in sera were measured in 76 asthmatics. The increased level of specific lgC4 was found in cases 10-40 years old sensitive to house dust mite and/or Candida albicans, in cases with steroid-dependent intractable asthma (SDIA) and in elderly cases. The frequency of SDIA was the highest in cases 41 to 60 years old with higher frequency of increased lgG4 antibodies. The results show that specific lgC4 increases in relation to IgE-mediated immune response, long-term steroid therapy, and aging. All of these conditions may induce depressed cell-mediated immunity.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalJournal of Asthma
Issue number5
Publication statusPublished - Jan 1 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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