An increased level of specific igg4 antibodies against candida albicans in patients with bronchial asthma

Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fumihiro Mitsunobu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Specific IgG4 antibodies against Candida albicans in sera were measured in 76 asthmatics. The increased level of specific lgC4 was found in cases 10-40 years old sensitive to house dust mite and/or Candida albicans, in cases with steroid-dependent intractable asthma (SDIA) and in elderly cases. The frequency of SDIA was the highest in cases 41 to 60 years old with higher frequency of increased lgG4 antibodies. The results show that specific lgC4 increases in relation to IgE-mediated immune response, long-term steroid therapy, and aging. All of these conditions may induce depressed cell-mediated immunity.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalJournal of Asthma
Volume29
Issue number5
DOIs
Publication statusPublished - 1992

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Candida albicans
Asthma
Immunoglobulin G
Steroids
Antibodies
Pyroglyphidae
Cellular Immunity
Immunoglobulin E
Serum
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

An increased level of specific igg4 antibodies against candida albicans in patients with bronchial asthma. / Tanizaki, Yoshiro; Kitani, Hikaru; Okazaki, Morihiro; Mifune, Takashi; Mitsunobu, Fumihiro.

In: Journal of Asthma, Vol. 29, No. 5, 1992, p. 343-348.

Research output: Contribution to journalArticle

Tanizaki, Yoshiro ; Kitani, Hikaru ; Okazaki, Morihiro ; Mifune, Takashi ; Mitsunobu, Fumihiro. / An increased level of specific igg4 antibodies against candida albicans in patients with bronchial asthma. In: Journal of Asthma. 1992 ; Vol. 29, No. 5. pp. 343-348.
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