An immunohistochemical study of copper, zinc‐containing superoxide dismutase detected by a monoclonal antibody in gastric mucosa and gastric cancer

S. OKA, K. OGINO, T. HOUBARA, S. YOSHIMURA, Y. OKAZAKI, T. TAKEMOTO, N. KATO, Y. IIDA, T. UDA

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10 Citations (Scopus)

Abstract

The immunohistochemical localization of copper, zinc‐superoxide dismutase (Cu, Zn‐SOD) in human gastric mucosa and gastric cancer was studied using a monoclonal antibody. In gastric mucosa, parietal cells, pyloric glandular cells and foci of intestinal metaplasia showed positive staining in the cytoplasm and/or nucleus. The wide distribution of Cu, Zn‐SOD in the gastric mucosa suggests cell function may be vulnerable to active oxygen species. In gastric cancer, 34 of 70 cases showed a positive reaction for Cu, Zn‐SOD. There was a relationship between the grade of Cu, Zn‐SOD immunoreactivity and the histological type of gastric cancer, well‐differentiated types of gastric cancer being more frequently positive. The positive cases of poorly‐differentiated adenocarcinoma were characterized by a pattern of diffusely infiltrative invasion. These results suggest that some types of gastric cancer are resistant to active oxygen species.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalHistopathology
Volume17
Issue number3
DOIs
Publication statusPublished - Sep 1990

Keywords

  • copper
  • gastric cancer
  • gastric mucosa
  • zinc‐superoxide dismutase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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