TY - JOUR
T1 - An immunohistochemical study of copper, zinc‐containing superoxide dismutase detected by a monoclonal antibody in gastric mucosa and gastric cancer
AU - OKA, S.
AU - OGINO, K.
AU - HOUBARA, T.
AU - YOSHIMURA, S.
AU - OKAZAKI, Y.
AU - TAKEMOTO, T.
AU - KATO, N.
AU - IIDA, Y.
AU - UDA, T.
PY - 1990/9
Y1 - 1990/9
N2 - The immunohistochemical localization of copper, zinc‐superoxide dismutase (Cu, Zn‐SOD) in human gastric mucosa and gastric cancer was studied using a monoclonal antibody. In gastric mucosa, parietal cells, pyloric glandular cells and foci of intestinal metaplasia showed positive staining in the cytoplasm and/or nucleus. The wide distribution of Cu, Zn‐SOD in the gastric mucosa suggests cell function may be vulnerable to active oxygen species. In gastric cancer, 34 of 70 cases showed a positive reaction for Cu, Zn‐SOD. There was a relationship between the grade of Cu, Zn‐SOD immunoreactivity and the histological type of gastric cancer, well‐differentiated types of gastric cancer being more frequently positive. The positive cases of poorly‐differentiated adenocarcinoma were characterized by a pattern of diffusely infiltrative invasion. These results suggest that some types of gastric cancer are resistant to active oxygen species.
AB - The immunohistochemical localization of copper, zinc‐superoxide dismutase (Cu, Zn‐SOD) in human gastric mucosa and gastric cancer was studied using a monoclonal antibody. In gastric mucosa, parietal cells, pyloric glandular cells and foci of intestinal metaplasia showed positive staining in the cytoplasm and/or nucleus. The wide distribution of Cu, Zn‐SOD in the gastric mucosa suggests cell function may be vulnerable to active oxygen species. In gastric cancer, 34 of 70 cases showed a positive reaction for Cu, Zn‐SOD. There was a relationship between the grade of Cu, Zn‐SOD immunoreactivity and the histological type of gastric cancer, well‐differentiated types of gastric cancer being more frequently positive. The positive cases of poorly‐differentiated adenocarcinoma were characterized by a pattern of diffusely infiltrative invasion. These results suggest that some types of gastric cancer are resistant to active oxygen species.
KW - copper
KW - gastric cancer
KW - gastric mucosa
KW - zinc‐superoxide dismutase
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UR - http://www.scopus.com/inward/citedby.url?scp=0025100237&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2559.1990.tb00712.x
DO - 10.1111/j.1365-2559.1990.tb00712.x
M3 - Article
C2 - 2173675
AN - SCOPUS:0025100237
SN - 0309-0167
VL - 17
SP - 231
EP - 236
JO - Histopathology
JF - Histopathology
IS - 3
ER -
