An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva

Akiko Ono; Goichi Tsukamoto; Hitoshi Nagatsuka; Yasuto Yoshihama; Rosario Santos Rivera; Miki Katsurano; Mayumi Yao; Akira Sasaki

doi:10.1016/j.oraloncology.2006.03.017

An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva

Akiko Ono, Goichi Tsukamoto, Hitoshi Nagatsuka, Yasuto Yoshihama, Rosario Santos Rivera, Miki Katsurano, Mayumi Yao, Akira Sasaki

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.

Original language	English
Pages (from-to)	339-344
Number of pages	6
Journal	Oral Oncology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.oraloncology.2006.03.017
Publication status	Published - Apr 2007

Keywords

Bone morphogenetic protein
Ossifying fibroma
Osteocalcin
Osteopontin
Oxytalan fiber
Peripheral cemento-ossifying fibroma
Proliferating cell nuclear antigen

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

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Ono, A., Tsukamoto, G., Nagatsuka, H., Yoshihama, Y., Rivera, R. S., Katsurano, M., Yao, M., & Sasaki, A. (2007). An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva. Oral Oncology, 43(4), 339-344. https://doi.org/10.1016/j.oraloncology.2006.03.017

An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva. / Ono, Akiko; Tsukamoto, Goichi; Nagatsuka, Hitoshi; Yoshihama, Yasuto; Rivera, Rosario Santos; Katsurano, Miki; Yao, Mayumi; Sasaki, Akira.

In: Oral Oncology, Vol. 43, No. 4, 04.2007, p. 339-344.

Research output: Contribution to journal › Article › peer-review

Ono, A, Tsukamoto, G, Nagatsuka, H, Yoshihama, Y, Rivera, RS, Katsurano, M, Yao, M & Sasaki, A 2007, 'An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva', Oral Oncology, vol. 43, no. 4, pp. 339-344. https://doi.org/10.1016/j.oraloncology.2006.03.017

Ono, Akiko ; Tsukamoto, Goichi ; Nagatsuka, Hitoshi ; Yoshihama, Yasuto ; Rivera, Rosario Santos ; Katsurano, Miki ; Yao, Mayumi ; Sasaki, Akira. / An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva. In: Oral Oncology. 2007 ; Vol. 43, No. 4. pp. 339-344.

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title = "An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva",

abstract = "The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.",

keywords = "Bone morphogenetic protein, Ossifying fibroma, Osteocalcin, Osteopontin, Oxytalan fiber, Peripheral cemento-ossifying fibroma, Proliferating cell nuclear antigen",

author = "Akiko Ono and Goichi Tsukamoto and Hitoshi Nagatsuka and Yasuto Yoshihama and Rivera, {Rosario Santos} and Miki Katsurano and Mayumi Yao and Akira Sasaki",

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AU - Nagatsuka, Hitoshi

AU - Yoshihama, Yasuto

AU - Rivera, Rosario Santos

AU - Katsurano, Miki

AU - Yao, Mayumi

AU - Sasaki, Akira

PY - 2007/4

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N2 - The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.

AB - The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.

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An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva

Abstract

Keywords

ASJC Scopus subject areas

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