An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva

Akiko Ono, Goichi Tsukamoto, Hitoshi Nagatsuka, Yasuto Yoshihama, Rosario Santos Rivera, Miki Katsurano, Mayumi Yao, Akira Sasaki

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16 Citations (Scopus)


The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytalan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontal tissue.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalOral Oncology
Issue number4
Publication statusPublished - Apr 2007



  • Bone morphogenetic protein
  • Ossifying fibroma
  • Osteocalcin
  • Osteopontin
  • Oxytalan fiber
  • Peripheral cemento-ossifying fibroma
  • Proliferating cell nuclear antigen

ASJC Scopus subject areas

  • Oncology

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