An evaluation of anesthetic fade in motor evoked potential monitoring in spinal deformity surgeries

Ryo Ugawa, Tomoyuki Takigawa, Hiroko Shimomiya, Takuma Ohnishi, Yuri Kurokawa, Yoshiaki Oda, Yasuyuki Shiozaki, Haruo Misawa, Masato Tanaka, Toshihumi Ozaki

Research output: Contribution to journalArticle

Abstract

Background: Intraoperative neuromonitoring using motor evoked potentials (MEP) satisfactorily detects motor tract integrity changes during spinal surgery. However, monitoring is affected by "anesthetic fade," in which the stimulation threshold increases because the waveform amplitude decreases with the accumulation of propofol. Therefore, the purpose of this study was to clarify the effect of anesthetic fade on transcranial MEPs by investigating the time-dependent changes of amplitude during spinal deformity surgeries. Methods: We retrospectively reviewed medical records of 142 spinal deformity patients (66 patients with idiopathic scoliosis, 28 with adult spinal deformities, 19 with neuromuscular scoliosis, 17 with syndromic scoliosis, and 12 with congenital scoliosis). The average age was 28years (range, 5 to 81years). MEPs were recorded bilaterally from the abductor digiti minimi (ADM) and abductor hallucis (AH) muscles during spinal deformity surgeries. The Wilcoxon signed-rank test was used to investigate the time-dependent changes of amplitude after propofol infusion to evaluate anesthetic fade effects. Results: The average time to baseline from initial propofol infusion was 113min (range, 45 to 182min). In the ADM, the amplitude was 52% at 1h after initial propofol infusion, 102% at 2h, 105% at 3h, 101% at 4h, 86% at 5h, and 81% at 6h. Compared to the 2-h time point, MEP decreased significantly by 16% at 5h (P<0.0005) and by 21% at 6h (P<0.05). In the AH, the amplitude was 49% at 1h after initial infusion of propofol, 102% at 2h, 102% at 3h, 92% at 4h, 71% at 5h, and 63% at 6h. Compared to the 2-h time point, MEP decreased significantly by 10% at 4h (P<0.005), by 31% at 5h (P<0.0000005), and by 39% at 6h (P<0.05). Conclusions: MEP amplitude significantly decreased in the upper limbs at 5 and 6h and in the lower limbs at 4, 5, and 6h after the initial infusion of propofol, respectively. The influence of anesthetic fade could influence false positive MEPs during long spinal surgeries.

Original languageEnglish
Article number227
JournalJournal of Orthopaedic Surgery and Research
Volume13
Issue number1
DOIs
Publication statusPublished - Sep 5 2018

Fingerprint

Motor Evoked Potentials
Propofol
Anesthetics
Scoliosis
Nonparametric Statistics
Upper Extremity
Medical Records
Lower Extremity
Muscles

Keywords

  • Abductor digiti minimi
  • Abductor hallucis
  • Alarm point
  • Amplitude
  • Anesthetic fade
  • False positive
  • Intraoperative neuromonitoring
  • Motor evoked potential
  • Propofol
  • Spinal deformity surgery

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

An evaluation of anesthetic fade in motor evoked potential monitoring in spinal deformity surgeries. / Ugawa, Ryo; Takigawa, Tomoyuki; Shimomiya, Hiroko; Ohnishi, Takuma; Kurokawa, Yuri; Oda, Yoshiaki; Shiozaki, Yasuyuki; Misawa, Haruo; Tanaka, Masato; Ozaki, Toshihumi.

In: Journal of Orthopaedic Surgery and Research, Vol. 13, No. 1, 227, 05.09.2018.

Research output: Contribution to journalArticle

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author = "Ryo Ugawa and Tomoyuki Takigawa and Hiroko Shimomiya and Takuma Ohnishi and Yuri Kurokawa and Yoshiaki Oda and Yasuyuki Shiozaki and Haruo Misawa and Masato Tanaka and Toshihumi Ozaki",
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AU - Ugawa, Ryo

AU - Takigawa, Tomoyuki

AU - Shimomiya, Hiroko

AU - Ohnishi, Takuma

AU - Kurokawa, Yuri

AU - Oda, Yoshiaki

AU - Shiozaki, Yasuyuki

AU - Misawa, Haruo

AU - Tanaka, Masato

AU - Ozaki, Toshihumi

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KW - Abductor hallucis

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KW - Anesthetic fade

KW - False positive

KW - Intraoperative neuromonitoring

KW - Motor evoked potential

KW - Propofol

KW - Spinal deformity surgery

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