Abstract
Background/Aims: Although mucosal healing (MH) has been considered a treatment goal for patients with ulcerative colitis (UC), the risk factors predictive of relapse in patients who achieve MH are unknown. Because the platelet count has been shown to be a marker of inflammation in inflammatory bowel diseases, this study aimed to assess whether the platelet count could predict relapse in UC patients with MH. Methods: A prospective observational study was performed. UC patients with MH were consecutively enrolled in the study and monitored for at least 2 years or until relapse. The correlation between the incidence of relapse and the platelet count at the time of study enrollment was examined. Results: In total, 43 patients were enrolled, and 14 patients (33%) relapsed. The median platelet count at the time of enrollment in the patients who relapsed significantly differed from that in the patients who did not relapse (27.2×104/ µL vs 23.8×104/µL, respectively; p=0.016). A platelet count >25.0×104/µL was a significant risk factor for relapse based on a multivariate analysis (hazard ratio, 4.85; 95% confidence interval, 1.07 to 25.28), and according to the Kaplan-Meier analysis, this cutoff could identify patients susceptible to relapse (p=0.041, log-rank test). Conclusions: The platelet count could be used as a predictor of relapse in UC patients with MH.
| Original language | English |
|---|---|
| Pages (from-to) | 420-425 |
| Number of pages | 6 |
| Journal | Gut and Liver |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2018 |
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Keywords
- Colitis
- Mucosal healing
- Platelet count
- Recurrence
- Ulcerative
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
An elevated platelet count increases the risk of relapse in ulcerative colitis patients with mucosal healing. / Nakarai, Asuka; Kato, Jun; Hiraoka, Sakiko; Takashima, Shiho; Inokuchi, Toshihiro; Takahara, Masahiro; Sugihara, Yuusaku; Harada, Keita; Okada, Hiroyuki.
In: Gut and Liver, Vol. 12, No. 4, 01.07.2018, p. 420-425.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An elevated platelet count increases the risk of relapse in ulcerative colitis patients with mucosal healing
AU - Nakarai, Asuka
AU - Kato, Jun
AU - Hiraoka, Sakiko
AU - Takashima, Shiho
AU - Inokuchi, Toshihiro
AU - Takahara, Masahiro
AU - Sugihara, Yuusaku
AU - Harada, Keita
AU - Okada, Hiroyuki
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Background/Aims: Although mucosal healing (MH) has been considered a treatment goal for patients with ulcerative colitis (UC), the risk factors predictive of relapse in patients who achieve MH are unknown. Because the platelet count has been shown to be a marker of inflammation in inflammatory bowel diseases, this study aimed to assess whether the platelet count could predict relapse in UC patients with MH. Methods: A prospective observational study was performed. UC patients with MH were consecutively enrolled in the study and monitored for at least 2 years or until relapse. The correlation between the incidence of relapse and the platelet count at the time of study enrollment was examined. Results: In total, 43 patients were enrolled, and 14 patients (33%) relapsed. The median platelet count at the time of enrollment in the patients who relapsed significantly differed from that in the patients who did not relapse (27.2×104/ µL vs 23.8×104/µL, respectively; p=0.016). A platelet count >25.0×104/µL was a significant risk factor for relapse based on a multivariate analysis (hazard ratio, 4.85; 95% confidence interval, 1.07 to 25.28), and according to the Kaplan-Meier analysis, this cutoff could identify patients susceptible to relapse (p=0.041, log-rank test). Conclusions: The platelet count could be used as a predictor of relapse in UC patients with MH.
AB - Background/Aims: Although mucosal healing (MH) has been considered a treatment goal for patients with ulcerative colitis (UC), the risk factors predictive of relapse in patients who achieve MH are unknown. Because the platelet count has been shown to be a marker of inflammation in inflammatory bowel diseases, this study aimed to assess whether the platelet count could predict relapse in UC patients with MH. Methods: A prospective observational study was performed. UC patients with MH were consecutively enrolled in the study and monitored for at least 2 years or until relapse. The correlation between the incidence of relapse and the platelet count at the time of study enrollment was examined. Results: In total, 43 patients were enrolled, and 14 patients (33%) relapsed. The median platelet count at the time of enrollment in the patients who relapsed significantly differed from that in the patients who did not relapse (27.2×104/ µL vs 23.8×104/µL, respectively; p=0.016). A platelet count >25.0×104/µL was a significant risk factor for relapse based on a multivariate analysis (hazard ratio, 4.85; 95% confidence interval, 1.07 to 25.28), and according to the Kaplan-Meier analysis, this cutoff could identify patients susceptible to relapse (p=0.041, log-rank test). Conclusions: The platelet count could be used as a predictor of relapse in UC patients with MH.
KW - Colitis
KW - Mucosal healing
KW - Platelet count
KW - Recurrence
KW - Ulcerative
UR - http://www.scopus.com/inward/record.url?scp=85049974849&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049974849&partnerID=8YFLogxK
U2 - 10.5009/gnl17236
DO - 10.5009/gnl17236
M3 - Article
C2 - 29945423
AN - SCOPUS:85049974849
VL - 12
SP - 420
EP - 425
JO - Gut and Liver
JF - Gut and Liver
SN - 1976-2283
IS - 4
ER -