An elderly patient with transient diabetes insipidus associated with lymphocytic infundibulo-neurohypophysitis

Masami Takahashi, Fumio Otsuka, Tomoko Miyoshi, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We present the eldest case ever reported of central diabetes insipidus (DI) associated with infundibulo-neurohypophysitis. A 77-year old woman, who complained of recent development of excessive thirst, polyuria and polydipsia, was referred to our hospital. The daily urine volume was markedly increased to 6 L. DDAVP administration effectively reduced urine volume and increased urine osmolality. The loading test using high-osmolar sodium chloride showed impaired excretion of vasopressin discordant with plasma osmolar changes. The anterior pituitary function was normal. Pituitary magnetic resonance imaging (MRI) showed thickening of the pituitary stalk and a lack of high-intensity signal of the neurohypophysis on T1-weighted images, suggestive of lymphocytic infundibulo-neurohypophysitis. The thickness of pituitary stalk on MRI improved 6 months later. DI was controlled with DDAVP for 40 days. This was followed by stabilization of the daily urine volume to less than 2.5 L without DDAVP. Our case is the eldest case of central DI associated with infundibulo-neurohypophysitis. The rapid remission of pituitary changes on MRI provides an insight that spontaneously partial remission of central DI may occur, resulting in transient polyuria and polydipsia.

Original languageEnglish
Pages (from-to)741-746
Number of pages6
JournalEndocrine Journal
Volume46
Issue number5
Publication statusPublished - Oct 1999

Fingerprint

Diabetes Insipidus
Neurogenic Diabetes Insipidus
Deamino Arginine Vasopressin
Urine
Polydipsia
Polyuria
Magnetic Resonance Imaging
Pituitary Gland
Thirst
Posterior Pituitary Gland
Vasopressins
Sodium Chloride
Osmolar Concentration

Keywords

  • High-aged onset
  • Lymphocytic infundibulo- neurohypophysitis
  • Magnetic resonance imaging (MRI)
  • Transient diabetes insipidus

ASJC Scopus subject areas

  • Endocrinology

Cite this

An elderly patient with transient diabetes insipidus associated with lymphocytic infundibulo-neurohypophysitis. / Takahashi, Masami; Otsuka, Fumio; Miyoshi, Tomoko; Ogura, Toshio; Makino, Hirofumi.

In: Endocrine Journal, Vol. 46, No. 5, 10.1999, p. 741-746.

Research output: Contribution to journalArticle

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