Abstract
(Matrix Presented) A highly efficient method for the cyclopentene annulation onto α,β-unsaturated ketones is described. Indium-mediated 1,4-propargylation onto α,β-unsaturated ketones in the presence of tert-butyldimethylsilyl triflate and dimethyl sulfide gives the 6-siloxy-5-en-1-yne derivatives, which undergo W(CO)5(L)-catalyzed 5-endo-dig cyclization to give the corresponding cyclopentene derivatives in good yield.
Original language | English |
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Pages (from-to) | 4463-4466 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 4 |
Issue number | 25 |
DOIs | |
Publication status | Published - Dec 12 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry