An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: A post-hoc analysis of a prospective randomized controlled trial

Shinya Yamada, Hisashi Doyama, Kenshi Yao, Noriya Uedo, Yasumasa Ezoe, Ichiro Oda, Kazuhiro Kaneko, Yoshiro Kawahara, Chizu Yokoi, Yasushi Sugiura, Hideki Ishikawa, Yoji Takeuchi, Yutaka Saito, Manabu Muto

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35 Citations (Scopus)

Abstract

Background We previously reported that magnifying narrow-band imaging (M-NBI) is a high-performance diagnostic tool for small, depressed gastric cancer. However, an efficient diagnostic strategy using endoscopic findings has not been fully elucidated. Objective To identify the endoscopic findings that contribute to accurate diagnosis of small, depressed gastric cancer and to propose the ideal diagnostic approach to such lesions. Design Post-hoc analysis of a prospective, randomized, controlled trial. Setting Nine hospitals. Patients Three hundred fifty-three patients with small, depressed gastric lesions. Interventions In the M-NBI group (n = 177), cancer diagnosis was made with diagnostic criteria including a demarcation line (DL) and an irregular microvascular pattern (IMVP). In the conventional white-light imaging (C-WLI) group (n = 176), diagnostic criteria were both an irregular margin and a spiny depressed area. In the C-WLI group, M-NBI was performed after C-WLI diagnosis. Main Outcome Measurements The diagnostic performance of each criterion in M-NBI alone, C-WLI, and M-NBI after C-WLI was investigated. Results M-NBI after C-WLI ultimately showed the best diagnostic performance in each diagnostic criterion. In M-NBI after C-WLI, evaluation of DL is technically easier than that of IMVP, and DL alone had a high sensitivity (95%) and negative predictive value (99%). The IMVP in M-NBI after C-WLI had a high sensitivity and specificity (95% and 96%, respectively) for diagnosis of cancer. Limitations Lesions were limited to the small, depressed type. Conclusions For a diagnosis using M-NBI after C-WLI, identification of DL is the first step, and subsequent inspection of IMVP diagnosed by DL is an efficient strategy.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalGastrointestinal Endoscopy
Volume79
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • C-WLI
  • DL
  • ESD
  • IM
  • IMVP
  • M-NBI
  • SDA
  • conventional white-light imaging
  • demarcation line
  • endoscopic submucosal dissection
  • irregular margin
  • irregular microvascular pattern
  • magnifying narrow-band imaging
  • spiny depressed area

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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  • Cite this

    Yamada, S., Doyama, H., Yao, K., Uedo, N., Ezoe, Y., Oda, I., Kaneko, K., Kawahara, Y., Yokoi, C., Sugiura, Y., Ishikawa, H., Takeuchi, Y., Saito, Y., & Muto, M. (2014). An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: A post-hoc analysis of a prospective randomized controlled trial. Gastrointestinal Endoscopy, 79(1), 55-63. https://doi.org/10.1016/j.gie.2013.07.008