An early history of Japanese amyotrophic lateral sclerosis (ALS)-related diseases and the current development

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Abstract

The present review focuses an early history of Japanese amyotrophic lateral sclerosis (ALS)-related diseases and the current development. In relation to foreign previous reports, five topics are introduced and discussed on ALS with dementia, ALS/Parkinsonism dementia complex (ALS/PDC), familial ALS (FALS), spinal bulbar muscular atrophy (SBMA), and multisystem involvement especially in cerebellar system of ALS including ALS/SCA (spinocerebellar ataxia) crossroad mutation Asidan. This review found the great contribution of Japanese reports on the above five topics, and confirmed the great development of ALS-related diseases over the past 120 years.

Original languageEnglish
Pages (from-to)141-165
Number of pages25
JournalClinical Neurology
Volume58
Issue number3
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • ALS
  • ALS/PDC
  • Asidan
  • FALS
  • SBMA

ASJC Scopus subject areas

  • Clinical Neurology

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