An autopsied case with orbital infiltration of leukemic cells after optic nerve invasion by acute T-cell leukemia

Noriko Sakaguchi, Masako Itami, Aiko Toda, Yuuichi Sumii, Kazuhiro Ikeuchi, Yoshikazu Yamamoto, Kazuhiko Yamamoto, Wakako Oda, Kenji Nishida, Shuhei Kimura

Research output: Contribution to journalArticle

Abstract

Purpose: To report a case of T-cell acute lymphoblastic leukemia (T-ALL) with optic nerve and orbital invasion. Case: A 46-year-old man was diagnosed as T-ALL in 2014, received chemotherapy, and obtained complete remission (CR). T-ALL relapsed with blurring vision of right eye 7months after diagnosis. He lost vision in the right eye due to central retinal artery occlusion. 2nd CR was achieved, then peripheral blood stem cell transfusion (PBSCT) was operated. However 2nd relapse was detected in meninges only 3 months after the PBSCT, presenting paropsia of left eye was progressed to proptosis and ophthalmalgia. Orbital MRI scan showed contrast enhancement in bilateral extraocular muscle, left orbital fat, and left optic nerve. After treatment, proptosis was regressed transiently. Despite he died by disease progress 19 months after diagnosis. Findings: Autopsy revealed systemic T-ALL involvement including eyeball and orbit. The immunostaining pattern was positive for CD3, MIC2, negative for CD20. Coagulation necrosis of optic nerve and involvement of T-ALL in orbital fat, uvea, retina and extraocular muscle were observed. Conclusion: An autopsy report indicating involvement of orbital mass with T-ALL is extremely rare, and regarded as worthy information.

Original languageEnglish
Pages (from-to)1203-1209
Number of pages7
JournalJapanese Journal of Clinical Ophthalmology
Volume71
Issue number8
Publication statusPublished - Aug 1 2017

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Leukemic Infiltration
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Optic Nerve
Oculomotor Muscles
Exophthalmos
Autopsy
Fats
Uvea
Retinal Artery Occlusion
Meninges
Orbit
Retina
Necrosis
Magnetic Resonance Imaging
Recurrence
Drug Therapy

ASJC Scopus subject areas

  • Ophthalmology

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An autopsied case with orbital infiltration of leukemic cells after optic nerve invasion by acute T-cell leukemia. / Sakaguchi, Noriko; Itami, Masako; Toda, Aiko; Sumii, Yuuichi; Ikeuchi, Kazuhiro; Yamamoto, Yoshikazu; Yamamoto, Kazuhiko; Oda, Wakako; Nishida, Kenji; Kimura, Shuhei.

In: Japanese Journal of Clinical Ophthalmology, Vol. 71, No. 8, 01.08.2017, p. 1203-1209.

Research output: Contribution to journalArticle

Sakaguchi, N, Itami, M, Toda, A, Sumii, Y, Ikeuchi, K, Yamamoto, Y, Yamamoto, K, Oda, W, Nishida, K & Kimura, S 2017, 'An autopsied case with orbital infiltration of leukemic cells after optic nerve invasion by acute T-cell leukemia', Japanese Journal of Clinical Ophthalmology, vol. 71, no. 8, pp. 1203-1209.
Sakaguchi, Noriko ; Itami, Masako ; Toda, Aiko ; Sumii, Yuuichi ; Ikeuchi, Kazuhiro ; Yamamoto, Yoshikazu ; Yamamoto, Kazuhiko ; Oda, Wakako ; Nishida, Kenji ; Kimura, Shuhei. / An autopsied case with orbital infiltration of leukemic cells after optic nerve invasion by acute T-cell leukemia. In: Japanese Journal of Clinical Ophthalmology. 2017 ; Vol. 71, No. 8. pp. 1203-1209.
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