An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify

Hisakazu Nishimori, Shunji Takahashi, Eijiro Nagasaki, Takayuki Kobayashi, Masahiro Yokoyama, Eiji Shinozaki, Yuko Mishima, Yasuhito Terui, Keisyo Chin, Nobuyuki Mizunuma, Yoshinori Ito, Kentaro Inamura, Kiyohiko Hatake

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Abstract

A 40-year-old man suffering from right cheek swelling was first diagnosed with ameloblastoma or anaplastic poorly-differentiated carcinoma of the head and neck region. He received 2 courses of CDDP/TXT chemotherapy (cisplatin 75 mg/m2, docetaxel 80 mg/m2) and achieved a partial response, but his carcinoma of the pancreas recurred. He also achieved a partial response with 2 courses of CBDCA/TXL regimen (carboplatin AUC=6, paclitaxel 200 mg/m2), but later died from his progressive disease. The autopsy revealed a pathological diagnosis of metastatic endocrine carcinoma of the pancreas. This case was close to a cancer with an unknown primary (CUP) site, and several favorable sub-sets of CUP have been identified, which are responsive to systemic chemotherapy. Poorly-differentiated neuroendocrine carcinomas like this case are highly sensitive to chemotherapy, and a careful pathological diagnosis may clarify its sensitivity to chemotherapy and the prognosis.

Original languageEnglish
Pages (from-to)671-673
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume32
Issue number5
Publication statusPublished - May 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Nishimori, H., Takahashi, S., Nagasaki, E., Kobayashi, T., Yokoyama, M., Shinozaki, E., Mishima, Y., Terui, Y., Chin, K., Mizunuma, N., Ito, Y., Inamura, K., & Hatake, K. (2005). An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify. Gan to kagaku ryoho. Cancer & chemotherapy, 32(5), 671-673.