An automata-based microscopic model inspired by clonal expansion

Francesco Zanlungo, Sandro Rambaldi, Giorgio Turchetti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We present a simple model based on microscopic automata to describe the clonal expansion process. The model is based on a repertoire of antigens and T lymphocytes interacting via antigen-presenting cells which present the antigens peptides. Each cell is represented by an automaton moving randomly on a two-dimensional lattice.We use this simplified model in order to introduce local and spatial considerations in the mathematical models of clonal expansion based on differential equations, and at the same time to attempt an analytical interpretation of the results of computer simulations. For this reason we also derive a mean field theory, whose results are in good agreement with the solutions of the microscopic model, at least for situations that are not too far from equilibrium. This model may be used as the basis of a more realistic one that could follow the clonal expansion process on a simplified version of the lymphatic network.

Original languageEnglish
Title of host publicationModeling and Simulation in Science, Engineering and Technology
PublisherSpringer Basel
Pages133-144
Number of pages12
Edition9780817645557
DOIs
Publication statusPublished - 2008
Externally publishedYes

Publication series

NameModeling and Simulation in Science, Engineering and Technology
Number9780817645557
ISSN (Print)2164-3679
ISSN (Electronic)2164-3725

Keywords

  • agent model
  • automata
  • Clonal expansion
  • competitive exclusion
  • differential equations

ASJC Scopus subject areas

  • Modelling and Simulation
  • Engineering(all)
  • Fluid Flow and Transfer Processes
  • Computational Mathematics

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