An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients

Junko Inagaki, Mayumi Sugiura-Ogasawara, Motoyoshi Nomizu, Mikiya Nakatsuka, Katsuo Ikuta, Nobuharu Suzuki, Keiko Kaihara, Kazuko Kobayashi, Tatsuji Yasuda, Yehuda Shoenfeld, Koji Aoki, Eiji Matsuura

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. Methods: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. Results: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-α1 chain G domain. mRNA encoding laminin-α1, -β1, and -γ1 chains was expressed in 90% of endometriotic lesions. Conclusions: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

Original languageEnglish
Pages (from-to)544-549
Number of pages6
JournalHuman Reproduction
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Fingerprint

Endometriosis
Autoantibodies
laminin 1
anti-IgG
Placentation
Messenger RNA
Spontaneous Abortion
First Pregnancy Trimester
Basement Membrane
Laparoscopy
Laparotomy
Infertility
Embryonic Development
Glycoproteins
Serum

Keywords

  • Anti-laminin-1 autoantibody
  • Endometriosis
  • Infertility
  • Miscarriage

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients. / Inagaki, Junko; Sugiura-Ogasawara, Mayumi; Nomizu, Motoyoshi; Nakatsuka, Mikiya; Ikuta, Katsuo; Suzuki, Nobuharu; Kaihara, Keiko; Kobayashi, Kazuko; Yasuda, Tatsuji; Shoenfeld, Yehuda; Aoki, Koji; Matsuura, Eiji.

In: Human Reproduction, Vol. 18, No. 3, 01.03.2003, p. 544-549.

Research output: Contribution to journalArticle

Inagaki, J, Sugiura-Ogasawara, M, Nomizu, M, Nakatsuka, M, Ikuta, K, Suzuki, N, Kaihara, K, Kobayashi, K, Yasuda, T, Shoenfeld, Y, Aoki, K & Matsuura, E 2003, 'An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients', Human Reproduction, vol. 18, no. 3, pp. 544-549. https://doi.org/10.1093/humrep/deg148
Inagaki, Junko ; Sugiura-Ogasawara, Mayumi ; Nomizu, Motoyoshi ; Nakatsuka, Mikiya ; Ikuta, Katsuo ; Suzuki, Nobuharu ; Kaihara, Keiko ; Kobayashi, Kazuko ; Yasuda, Tatsuji ; Shoenfeld, Yehuda ; Aoki, Koji ; Matsuura, Eiji. / An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients. In: Human Reproduction. 2003 ; Vol. 18, No. 3. pp. 544-549.
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AU - Sugiura-Ogasawara, Mayumi

AU - Nomizu, Motoyoshi

AU - Nakatsuka, Mikiya

AU - Ikuta, Katsuo

AU - Suzuki, Nobuharu

AU - Kaihara, Keiko

AU - Kobayashi, Kazuko

AU - Yasuda, Tatsuji

AU - Shoenfeld, Yehuda

AU - Aoki, Koji

AU - Matsuura, Eiji

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N2 - Background: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. Methods: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. Results: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-α1 chain G domain. mRNA encoding laminin-α1, -β1, and -γ1 chains was expressed in 90% of endometriotic lesions. Conclusions: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

AB - Background: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. Methods: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. Results: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-α1 chain G domain. mRNA encoding laminin-α1, -β1, and -γ1 chains was expressed in 90% of endometriotic lesions. Conclusions: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

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