An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats

A 28-day repeated dose test and reproduction/developmental toxicity test

Mariko Matsumoto, Makiko Yamaguchi, Yuka Yoshida, Mika Senuma, Hiromasa Takashima, Tomoko Kawamura, Hina Kato, Mika Takahashi, Mutsuko Hirata-Koizumi, Atsushi Ono, Kazuhito Yokoyama, Akihiko Hirose

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28. days at 0, 100, 300, or 1000. mg/kg bw/day or for a total of 42-46. days at 0, 8, 50, or 300. mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000. mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300. mg/kg bw/day. Another female delivered only three live pups at 300. mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300. mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8. mg/kg bw/day, respectively.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalFood and Chemical Toxicology
Volume56
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Fingerprint

developmental toxicity
Toxicity Tests
toxicity testing
biphenyl
Reproduction
Toxicity
Rats
labor
Antioxidants
Personnel
antioxidants
rats
Piloerection
dosage
Dystocia
No-Observed-Adverse-Effect Level
Pregnancy
testing
Hypothermia
no observed adverse effect level

Keywords

  • Gestation period
  • N,N'-diphenyl-p-phenylenediamine
  • Prostaglandin
  • Repeated dose toxicity
  • Reproductive toxicity

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats : A 28-day repeated dose test and reproduction/developmental toxicity test. / Matsumoto, Mariko; Yamaguchi, Makiko; Yoshida, Yuka; Senuma, Mika; Takashima, Hiromasa; Kawamura, Tomoko; Kato, Hina; Takahashi, Mika; Hirata-Koizumi, Mutsuko; Ono, Atsushi; Yokoyama, Kazuhito; Hirose, Akihiko.

In: Food and Chemical Toxicology, Vol. 56, 06.2013, p. 290-296.

Research output: Contribution to journalArticle

Matsumoto, M, Yamaguchi, M, Yoshida, Y, Senuma, M, Takashima, H, Kawamura, T, Kato, H, Takahashi, M, Hirata-Koizumi, M, Ono, A, Yokoyama, K & Hirose, A 2013, 'An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test', Food and Chemical Toxicology, vol. 56, pp. 290-296. https://doi.org/10.1016/j.fct.2013.02.029
Matsumoto, Mariko ; Yamaguchi, Makiko ; Yoshida, Yuka ; Senuma, Mika ; Takashima, Hiromasa ; Kawamura, Tomoko ; Kato, Hina ; Takahashi, Mika ; Hirata-Koizumi, Mutsuko ; Ono, Atsushi ; Yokoyama, Kazuhito ; Hirose, Akihiko. / An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats : A 28-day repeated dose test and reproduction/developmental toxicity test. In: Food and Chemical Toxicology. 2013 ; Vol. 56. pp. 290-296.
@article{3f1e25fe9f7d444aa2c028033706c891,
title = "An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test",
abstract = "A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28. days at 0, 100, 300, or 1000. mg/kg bw/day or for a total of 42-46. days at 0, 8, 50, or 300. mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000. mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300. mg/kg bw/day. Another female delivered only three live pups at 300. mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300. mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8. mg/kg bw/day, respectively.",
keywords = "Gestation period, N,N'-diphenyl-p-phenylenediamine, Prostaglandin, Repeated dose toxicity, Reproductive toxicity",
author = "Mariko Matsumoto and Makiko Yamaguchi and Yuka Yoshida and Mika Senuma and Hiromasa Takashima and Tomoko Kawamura and Hina Kato and Mika Takahashi and Mutsuko Hirata-Koizumi and Atsushi Ono and Kazuhito Yokoyama and Akihiko Hirose",
year = "2013",
month = "6",
doi = "10.1016/j.fct.2013.02.029",
language = "English",
volume = "56",
pages = "290--296",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats

T2 - A 28-day repeated dose test and reproduction/developmental toxicity test

AU - Matsumoto, Mariko

AU - Yamaguchi, Makiko

AU - Yoshida, Yuka

AU - Senuma, Mika

AU - Takashima, Hiromasa

AU - Kawamura, Tomoko

AU - Kato, Hina

AU - Takahashi, Mika

AU - Hirata-Koizumi, Mutsuko

AU - Ono, Atsushi

AU - Yokoyama, Kazuhito

AU - Hirose, Akihiko

PY - 2013/6

Y1 - 2013/6

N2 - A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28. days at 0, 100, 300, or 1000. mg/kg bw/day or for a total of 42-46. days at 0, 8, 50, or 300. mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000. mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300. mg/kg bw/day. Another female delivered only three live pups at 300. mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300. mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8. mg/kg bw/day, respectively.

AB - A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28. days at 0, 100, 300, or 1000. mg/kg bw/day or for a total of 42-46. days at 0, 8, 50, or 300. mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000. mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300. mg/kg bw/day. Another female delivered only three live pups at 300. mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300. mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8. mg/kg bw/day, respectively.

KW - Gestation period

KW - N,N'-diphenyl-p-phenylenediamine

KW - Prostaglandin

KW - Repeated dose toxicity

KW - Reproductive toxicity

UR - http://www.scopus.com/inward/record.url?scp=84875541606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875541606&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2013.02.029

DO - 10.1016/j.fct.2013.02.029

M3 - Article

VL - 56

SP - 290

EP - 296

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -