TY - JOUR
T1 - An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats
T2 - A 28-day repeated dose test and reproduction/developmental toxicity test
AU - Matsumoto, Mariko
AU - Yamaguchi, Makiko
AU - Yoshida, Yuka
AU - Senuma, Mika
AU - Takashima, Hiromasa
AU - Kawamura, Tomoko
AU - Kato, Hina
AU - Takahashi, Mika
AU - Hirata-Koizumi, Mutsuko
AU - Ono, Atsushi
AU - Yokoyama, Kazuhito
AU - Hirose, Akihiko
N1 - Funding Information:
This study was supported by the Ministry of Health, Labour and Welfare, Japan.
PY - 2013/6
Y1 - 2013/6
N2 - A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28. days at 0, 100, 300, or 1000. mg/kg bw/day or for a total of 42-46. days at 0, 8, 50, or 300. mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000. mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300. mg/kg bw/day. Another female delivered only three live pups at 300. mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300. mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8. mg/kg bw/day, respectively.
AB - A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28. days at 0, 100, 300, or 1000. mg/kg bw/day or for a total of 42-46. days at 0, 8, 50, or 300. mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000. mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300. mg/kg bw/day. Another female delivered only three live pups at 300. mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300. mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8. mg/kg bw/day, respectively.
KW - Gestation period
KW - N,N'-diphenyl-p-phenylenediamine
KW - Prostaglandin
KW - Repeated dose toxicity
KW - Reproductive toxicity
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U2 - 10.1016/j.fct.2013.02.029
DO - 10.1016/j.fct.2013.02.029
M3 - Article
C2 - 23454298
AN - SCOPUS:84875541606
SN - 0278-6915
VL - 56
SP - 290
EP - 296
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -