An analysis of DNA ploidy pattern of hepatocellular carcinoma.

K. Hamazaki, T. Kato, Y. Yunoki, M. Mori, A. Gochi, H. Mimura, K. Orita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p <0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalActa Medica Okayama
Volume47
Issue number6
Publication statusPublished - Dec 1993

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Ploidies
Hepatocellular Carcinoma
DNA
Blood Vessels
Neoplasm Metastasis
Hepatitis B Antigens
alpha-Fetoproteins
Viruses
Liver
Paraffin
Hepatectomy
Aneuploidy
Tumors
Diploidy
Hepatitis B virus
Liver Cirrhosis
Colonic Neoplasms
Stomach Neoplasms
Survival Rate
Antigens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hamazaki, K., Kato, T., Yunoki, Y., Mori, M., Gochi, A., Mimura, H., & Orita, K. (1993). An analysis of DNA ploidy pattern of hepatocellular carcinoma. Acta Medica Okayama, 47(6), 413-416.

An analysis of DNA ploidy pattern of hepatocellular carcinoma. / Hamazaki, K.; Kato, T.; Yunoki, Y.; Mori, M.; Gochi, A.; Mimura, H.; Orita, K.

In: Acta Medica Okayama, Vol. 47, No. 6, 12.1993, p. 413-416.

Research output: Contribution to journalArticle

Hamazaki, K, Kato, T, Yunoki, Y, Mori, M, Gochi, A, Mimura, H & Orita, K 1993, 'An analysis of DNA ploidy pattern of hepatocellular carcinoma.', Acta Medica Okayama, vol. 47, no. 6, pp. 413-416.
Hamazaki K, Kato T, Yunoki Y, Mori M, Gochi A, Mimura H et al. An analysis of DNA ploidy pattern of hepatocellular carcinoma. Acta Medica Okayama. 1993 Dec;47(6):413-416.
Hamazaki, K. ; Kato, T. ; Yunoki, Y. ; Mori, M. ; Gochi, A. ; Mimura, H. ; Orita, K. / An analysis of DNA ploidy pattern of hepatocellular carcinoma. In: Acta Medica Okayama. 1993 ; Vol. 47, No. 6. pp. 413-416.
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