An analysis of DNA ploidy pattern of hepatocellular carcinoma.

K. Hamazaki, T. Kato, Y. Yunoki, M. Mori, A. Gochi, H. Mimura, K. Orita

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3 Citations (Scopus)

Abstract

To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p < 0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalActa medica Okayama
Volume47
Issue number6
Publication statusPublished - Dec 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Hamazaki, K., Kato, T., Yunoki, Y., Mori, M., Gochi, A., Mimura, H., & Orita, K. (1993). An analysis of DNA ploidy pattern of hepatocellular carcinoma. Acta medica Okayama, 47(6), 413-416.