An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line

Katsuyuki Kiura, Shinobu Watarai, Hiroshi Ueoka, Masahiro Tabata, Ken Ichi Gemba, Keisuke Aoe, Hiromichi Yamane, Tatsuji Yasuda, Mine Harada

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19 Citations (Scopus)

Abstract

Previously we established cell lines resistant to Adriamycin and cisplatin to elucidate the mechanisins involved in acquired drug-resistance. In this study, we investigated ganglioside composition in drug-resistant cell lines. The Adriamycin-resistant cell line, SBC-3/ADM100, exhibited a ganglioside composition ratio similar to that of the parent SBC-3 cells. Densitometric analysis by resorcinol showed a 1.61-fold increase of ganglioside GM2 in SBC-3/ADM100 cells, when compared to the parent SBC-3 cells. The cisplatin-resistant cell line, SBC-3/CDDP, showed a simplified ganglioside pattern, expressing only gangliosides GM3 and GM2. SBC-3/CDDP cells showed a marked increase in ganglioside GM3. These findings suggest that the alteration of ganglioside composition may be actively involved in the acquisition of drug-resistance.

Original languageEnglish
Pages (from-to)2957-2960
Number of pages4
JournalAnticancer Research
Volume18
Issue number4 C
Publication statusPublished - Jul 1998

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Keywords

  • Cisplatin
  • Ganglioside
  • GM3
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kiura, K., Watarai, S., Ueoka, H., Tabata, M., Gemba, K. I., Aoe, K., Yamane, H., Yasuda, T., & Harada, M. (1998). An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line. Anticancer Research, 18(4 C), 2957-2960.