Amylin

Maho Ogoshi

doi:10.1016/B978-0-12-801028-0.00175-6

Amylin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

AMY is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and amidated C-terminus, which are common to the family members. AMY is co-secreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of islet amyloid in patients with type 2 diabetes. The human AMY 20–29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for treatment of type 1 and type 2 diabetes. AMY KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	245,e27F-1-246,e27F-3
ISBN (Electronic)	9780128010280
ISBN (Print)	9780128010679
DOIs	https://doi.org/10.1016/B978-0-12-801028-0.00175-6
Publication status	Published - Jan 1 2015

Keywords

glucose homeostasis
insulin
islet amyloid
pancreas
type 2 diabetes

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-801028-0.00175-6

Cite this

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AB - AMY is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and amidated C-terminus, which are common to the family members. AMY is co-secreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of islet amyloid in patients with type 2 diabetes. The human AMY 20–29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for treatment of type 1 and type 2 diabetes. AMY KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.

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Amylin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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