Amylase secretion induced by histamine from guinea-pig parotid gland

K. Saeki, S. Ikeda, S. Seo, M. Murakami, M. Nishibori

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3 Citations (Scopus)


The mode of action of histamine and its analogues on the secretion of amylase from guinea-pig parotid gland was studied in vitro using chopped parotid tissue. Histamine, 4-methylhistamine and 2-(2-pyridyl)ethylamine dose-dependently stimulated the secretion of amylase in the presence of 3-isobutyl-1-methylxanthine. The effect of histamine was blocked by mepyramine but not by metiamide. The effect of 4-methylhistamine was not inhibited by metiamide. Propranolol inhibited the effect of higher concentrations of histamine and 2-(2-pyridyl)ethylamine. A combination of mepyramine and propranolol markedly suppressed the effect of histamine and 2-(2-pyridyl)ethylamine. Atropine, phentolamine and tetrodotoxin had no influence on the histamine-induced secretion of amylase.

Original languageEnglish
Pages (from-to)4-15
Number of pages12
JournalArchives Internationales de Pharmacodynamie et de Therapie
Issue number1
Publication statusPublished - Apr 16 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology


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