Abstract
The mode of action of histamine and its analogues on the secretion of amylase from guinea-pig parotid gland was studied in vitro using chopped parotid tissue. Histamine, 4-methylhistamine and 2-(2-pyridyl)ethylamine dose-dependently stimulated the secretion of amylase in the presence of 3-isobutyl-1-methylxanthine. The effect of histamine was blocked by mepyramine but not by metiamide. The effect of 4-methylhistamine was not inhibited by metiamide. Propranolol inhibited the effect of higher concentrations of histamine and 2-(2-pyridyl)ethylamine. A combination of mepyramine and propranolol markedly suppressed the effect of histamine and 2-(2-pyridyl)ethylamine. Atropine, phentolamine and tetrodotoxin had no influence on the histamine-induced secretion of amylase.
| Original language | English |
|---|---|
| Pages (from-to) | 4-15 |
| Number of pages | 12 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 255 |
| Issue number | 1 |
| Publication status | Published - Apr 16 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology