Amylase secretion induced by histamine from guinea-pig parotid gland

K. Saeki, S. Ikeda, S. Seo, M. Murakami, Masahiro Nishibori

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The mode of action of histamine and its analogues on the secretion of amylase from guinea-pig parotid gland was studied in vitro using chopped parotid tissue. Histamine, 4-methylhistamine and 2-(2-pyridyl)ethylamine dose-dependently stimulated the secretion of amylase in the presence of 3-isobutyl-1-methylxanthine. The effect of histamine was blocked by mepyramine but not by metiamide. The effect of 4-methylhistamine was not inhibited by metiamide. Propranolol inhibited the effect of higher concentrations of histamine and 2-(2-pyridyl)ethylamine. A combination of mepyramine and propranolol markedly suppressed the effect of histamine and 2-(2-pyridyl)ethylamine. Atropine, phentolamine and tetrodotoxin had no influence on the histamine-induced secretion of amylase.

Original languageEnglish
Pages (from-to)4-15
Number of pages12
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume255
Issue number1
Publication statusPublished - 1982
Externally publishedYes

Fingerprint

Parotid Gland
Amylases
Histamine
Guinea Pigs
Metiamide
Pyrilamine
Propranolol
1-Methyl-3-isobutylxanthine
Phentolamine
Tetrodotoxin
Atropine
2-(2-aminoethyl)pyridine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Amylase secretion induced by histamine from guinea-pig parotid gland. / Saeki, K.; Ikeda, S.; Seo, S.; Murakami, M.; Nishibori, Masahiro.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 255, No. 1, 1982, p. 4-15.

Research output: Contribution to journalArticle

@article{56892f9ee47d427a9da2775c8c0ab0f9,
title = "Amylase secretion induced by histamine from guinea-pig parotid gland",
abstract = "The mode of action of histamine and its analogues on the secretion of amylase from guinea-pig parotid gland was studied in vitro using chopped parotid tissue. Histamine, 4-methylhistamine and 2-(2-pyridyl)ethylamine dose-dependently stimulated the secretion of amylase in the presence of 3-isobutyl-1-methylxanthine. The effect of histamine was blocked by mepyramine but not by metiamide. The effect of 4-methylhistamine was not inhibited by metiamide. Propranolol inhibited the effect of higher concentrations of histamine and 2-(2-pyridyl)ethylamine. A combination of mepyramine and propranolol markedly suppressed the effect of histamine and 2-(2-pyridyl)ethylamine. Atropine, phentolamine and tetrodotoxin had no influence on the histamine-induced secretion of amylase.",
author = "K. Saeki and S. Ikeda and S. Seo and M. Murakami and Masahiro Nishibori",
year = "1982",
language = "English",
volume = "255",
pages = "4--15",
journal = "Archives Internationales de Pharmacodynamie et de Therapie",
issn = "0003-9780",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Amylase secretion induced by histamine from guinea-pig parotid gland

AU - Saeki, K.

AU - Ikeda, S.

AU - Seo, S.

AU - Murakami, M.

AU - Nishibori, Masahiro

PY - 1982

Y1 - 1982

N2 - The mode of action of histamine and its analogues on the secretion of amylase from guinea-pig parotid gland was studied in vitro using chopped parotid tissue. Histamine, 4-methylhistamine and 2-(2-pyridyl)ethylamine dose-dependently stimulated the secretion of amylase in the presence of 3-isobutyl-1-methylxanthine. The effect of histamine was blocked by mepyramine but not by metiamide. The effect of 4-methylhistamine was not inhibited by metiamide. Propranolol inhibited the effect of higher concentrations of histamine and 2-(2-pyridyl)ethylamine. A combination of mepyramine and propranolol markedly suppressed the effect of histamine and 2-(2-pyridyl)ethylamine. Atropine, phentolamine and tetrodotoxin had no influence on the histamine-induced secretion of amylase.

AB - The mode of action of histamine and its analogues on the secretion of amylase from guinea-pig parotid gland was studied in vitro using chopped parotid tissue. Histamine, 4-methylhistamine and 2-(2-pyridyl)ethylamine dose-dependently stimulated the secretion of amylase in the presence of 3-isobutyl-1-methylxanthine. The effect of histamine was blocked by mepyramine but not by metiamide. The effect of 4-methylhistamine was not inhibited by metiamide. Propranolol inhibited the effect of higher concentrations of histamine and 2-(2-pyridyl)ethylamine. A combination of mepyramine and propranolol markedly suppressed the effect of histamine and 2-(2-pyridyl)ethylamine. Atropine, phentolamine and tetrodotoxin had no influence on the histamine-induced secretion of amylase.

UR - http://www.scopus.com/inward/record.url?scp=0020082015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020082015&partnerID=8YFLogxK

M3 - Article

C2 - 6176195

AN - SCOPUS:0020082015

VL - 255

SP - 4

EP - 15

JO - Archives Internationales de Pharmacodynamie et de Therapie

JF - Archives Internationales de Pharmacodynamie et de Therapie

SN - 0003-9780

IS - 1

ER -