Amygdaloid kindling and cerebrospinal cyclic nucleotides

M. Sato, Tomoyuki Akiyama, M. Yamashita, M. Okamoto, S. Otsuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The kindling model of experimental epilepsy is characterized by a persistent seizure pattern and long-lasting seizure susceptibility without associated tissue damage. In order to examine the relationship between CSF cyclic nucleotides and epilepsy, CSF cAMP and cGMP were measured before and after kindling, or after electronically induced seizures. Cyclic AMP and cGMP levels in cisternal CSF decreased significantly 1 week after the amygdaloid kindling. This finding suggests decreased levels of brain cAMP and cGMP in this type of epileptogenesis. A slight increase in CSF cyclic nucleotide concentrations was found after triggering both partial and generalized seizures. There was, however, no difference in increase of cAMP and cGMP levels between partial seizure and generalized convulsion, indicating that differences in intensity of ictal or postictal events cannot be reflected in the CSF cyclic nucleotide concentrations.

Original languageEnglish
Pages (from-to)763-771
Number of pages9
JournalBiological Psychiatry
Volume16
Issue number8
Publication statusPublished - 1981

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Cyclic Nucleotides
Seizures
Epilepsy
Cyclic AMP
Theoretical Models
Stroke
Brain

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Sato, M., Akiyama, T., Yamashita, M., Okamoto, M., & Otsuki, S. (1981). Amygdaloid kindling and cerebrospinal cyclic nucleotides. Biological Psychiatry, 16(8), 763-771.

Amygdaloid kindling and cerebrospinal cyclic nucleotides. / Sato, M.; Akiyama, Tomoyuki; Yamashita, M.; Okamoto, M.; Otsuki, S.

In: Biological Psychiatry, Vol. 16, No. 8, 1981, p. 763-771.

Research output: Contribution to journalArticle

Sato, M, Akiyama, T, Yamashita, M, Okamoto, M & Otsuki, S 1981, 'Amygdaloid kindling and cerebrospinal cyclic nucleotides', Biological Psychiatry, vol. 16, no. 8, pp. 763-771.
Sato M, Akiyama T, Yamashita M, Okamoto M, Otsuki S. Amygdaloid kindling and cerebrospinal cyclic nucleotides. Biological Psychiatry. 1981;16(8):763-771.
Sato, M. ; Akiyama, Tomoyuki ; Yamashita, M. ; Okamoto, M. ; Otsuki, S. / Amygdaloid kindling and cerebrospinal cyclic nucleotides. In: Biological Psychiatry. 1981 ; Vol. 16, No. 8. pp. 763-771.
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