Amphidinolide V, novel 14-membered macrolide from marine dinoflagellate Amphidinium sp.

Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A novel 14-membered polyene macrolide, amphidinolide V (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data. The relative stereochemistry of C-8, C-9, C-10, and C-13 was elucidated by NOESY correlations. Amphidinolide V (1) possessing five exo-methylenes and one epoxide exhibited cytotoxicity against tumor cell lines. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number5
DOIs
Publication statusPublished - Jan 29 2000
Externally publishedYes

Keywords

  • Cytotoxic
  • Macrolide
  • Marine dinoflagellate
  • Polyene

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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