Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.

Takaaki Kubota, Takahiro Iwai, Kanae Sakai, Tohru Gonoi, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Four new polyketides, amphidinins C-F (1-4), have been isolated from the culture broth of symbiotic dinoflagellate Amphidinium sp. The analysis of their spectral data revealed that amphidinins C-F (1-4) were 4,5-seco-analogues of amphidinolide Q (5). The absolute configurations of the new compounds were elucidated by the combination of J-based configuration analysis, modified Mosher's method, and chemical derivatization. Amphidinins D (2) and F (4) are the first glycosides related to amphidinolides. Amphidinins C-F (1-4) showed antimicrobial activity against bacteria and/or fungi.

Original languageEnglish
Pages (from-to)5624-5627
Number of pages4
JournalOrganic Letters
Volume16
Issue number21
DOIs
Publication statusPublished - Nov 7 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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