Amphidinin G, a putative biosynthetic precursor of amphidinin A from marine dinoflagellate Amphidinium sp.

Takaaki Kubota, Takahiro Iwai, Haruaki Ishiyama, Kanae Sakai, Tohru Gonoi, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A new linear polyketide, amphidinin G (1), has been isolated from a symbiotic marine dinoflagellate Amphidinium sp. The planar structure of 1 was established mainly based on the 2D NMR data and the stereochemistry was elucidated by the combination of J-value analysis, modified Mosher's method, and NMR chemical shift comparison with synthetic analogues. Amphidinin G (1) was expected to be a biosynthetic precursor of amphidinin A (2), a known linear dinoflagellate polyketide. Amphidinin G (1) showed antifungal activity against Trichophyton mentagrophytes.

Original languageEnglish
Pages (from-to)990-993
Number of pages4
JournalTetrahedron Letters
Volume56
Issue number8
DOIs
Publication statusPublished - Feb 18 2015
Externally publishedYes

Keywords

  • Amphidinium sp.
  • Antifungal
  • Biosynthetic precursor
  • Dinoflagellate
  • Linear polyketide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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