Abstract
A new linear polyketide, amphidinin G (1), has been isolated from a symbiotic marine dinoflagellate Amphidinium sp. The planar structure of 1 was established mainly based on the 2D NMR data and the stereochemistry was elucidated by the combination of J-value analysis, modified Mosher's method, and NMR chemical shift comparison with synthetic analogues. Amphidinin G (1) was expected to be a biosynthetic precursor of amphidinin A (2), a known linear dinoflagellate polyketide. Amphidinin G (1) showed antifungal activity against Trichophyton mentagrophytes.
Original language | English |
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Pages (from-to) | 990-993 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue number | 8 |
DOIs | |
Publication status | Published - Feb 18 2015 |
Externally published | Yes |
Keywords
- Amphidinium sp.
- Antifungal
- Biosynthetic precursor
- Dinoflagellate
- Linear polyketide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry