Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

Takaaki Kubota, Yusuke Sakuma, Kazutaka Shimbo, Masashi Tsuda, Michiko Nakano, Yasuhiro Uozumi, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Amphezonol A (1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A (1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C60-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A (1) exhibited a modest inhibitory activity against DNA polymerase α.

Original languageEnglish
Pages (from-to)4369-4371
Number of pages3
JournalTetrahedron Letters
Volume47
Issue number26
DOIs
Publication statusPublished - Jun 26 2006
Externally publishedYes

Keywords

  • Amphezonol A
  • Amphidinium sp.
  • Dinoflagellate
  • Polyhydroxyl metabolite

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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