Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats

Yoshito Zamami, Hiroki Fujiwara, Miho Hosoda, Hayato Hino, Kazuhiro Hirai, Kazuaki Okamoto, Xin Jin, Shingo Takatori, Shima Doi-Takaki, Hiromu Kawasaki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance.

Original languageEnglish
Pages (from-to)833-840
Number of pages8
JournalYakugaku Zasshi
Issue number6
Publication statusPublished - Jun 2010
Externally publishedYes


  • Insulin resistance
  • Mesenteric vascular bed
  • Otsuka long-evans tokushima fatty rat
  • Periarterial nerve function
  • Propolis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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