Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene transfer

Kumiko Ikeda, Jun Tohyama, Seiichi Tsujlno, Kahei Sato, Takashi Oono, Jirô Arata, Fumio Endo, Norio Sakuragawa

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6 Citations (Scopus)

Abstract

Prolidase deficiency is an autosomal recessive inherited disease characterized clinically by frequent infections, mental retardation, and various skin lesions. Fundamental treatments for these manifestations have not been established. We performed adenovirus-mediated gene transfer of human prolidase cDNA into fibroblasts from patients with prolidase deficiency. Infection with the adenovirus vector carrying human prolidase cDNA increased prolidase activity in fibroblasts UP to approximately 7.5 times of that of normal control fibroblasts. This indicates the feasibility of adenovirus- mediated gene therapy to treat patients with prolidase deficiency in the future.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalJapanese Journal of Human Genetics
Volume42
Issue number3
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • Adenovirus vector
  • Gene therapy
  • Prolidase deficiency

ASJC Scopus subject areas

  • Genetics(clinical)

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    Ikeda, K., Tohyama, J., Tsujlno, S., Sato, K., Oono, T., Arata, J., Endo, F., & Sakuragawa, N. (1997). Amelioration of prolidase deficiency in fibroblasts using adenovirus mediated gene transfer. Japanese Journal of Human Genetics, 42(3), 401-408. https://doi.org/10.1007/BF02766940