Alzheimer's disease and melatonin

Etsuro Matsubara; Mikio Shoji; Tetsuro Murakami; Takeshi Kawarabayashi; Koji Abe

doi:10.1016/S0531-5131(03)00019-0

Alzheimer's disease and melatonin

Etsuro Matsubara, Mikio Shoji, Tetsuro Murakami, Takeshi Kawarabayashi, Koji Abe

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Melatonin has a two different mechanism of action to prevent pro-amyloidogenic environment that leads to Alzheimer's amyloid β (Aβ) amyloidosis: (1) anti-amyloidogenic and (2) anti-oxidant properties. The former causes the reduction of the β-sheet-rich conformer which becomes aggregated and neurotoxic, contributing to neuroprotection. The latter also results in the reduction of neuronal damage mediated by Aβ-mediated oxidative stress. These strong neuroprotective effects may bear relevance to pathogenesis and therapy of Alzheimer's disease (AD). This review focuses on melatonin as a therapeutic agent for Alzheimer's disease.

Original language	English
Pages (from-to)	395-398
Number of pages	4
Journal	International Congress Series
Volume	1252
Issue number	C
DOIs	https://doi.org/10.1016/S0531-5131(03)00019-0
Publication status	Published - Jun 1 2003
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid β
Anti-amyloidogenic properties of melatonin
Antioxidant properties of melatonin
Melatonin

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0531-5131(03)00019-0

Cite this

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title = "Alzheimer's disease and melatonin",

abstract = "Melatonin has a two different mechanism of action to prevent pro-amyloidogenic environment that leads to Alzheimer's amyloid β (Aβ) amyloidosis: (1) anti-amyloidogenic and (2) anti-oxidant properties. The former causes the reduction of the β-sheet-rich conformer which becomes aggregated and neurotoxic, contributing to neuroprotection. The latter also results in the reduction of neuronal damage mediated by Aβ-mediated oxidative stress. These strong neuroprotective effects may bear relevance to pathogenesis and therapy of Alzheimer's disease (AD). This review focuses on melatonin as a therapeutic agent for Alzheimer's disease.",

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T1 - Alzheimer's disease and melatonin

AU - Matsubara, Etsuro

AU - Shoji, Mikio

AU - Murakami, Tetsuro

AU - Kawarabayashi, Takeshi

AU - Abe, Koji

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Melatonin has a two different mechanism of action to prevent pro-amyloidogenic environment that leads to Alzheimer's amyloid β (Aβ) amyloidosis: (1) anti-amyloidogenic and (2) anti-oxidant properties. The former causes the reduction of the β-sheet-rich conformer which becomes aggregated and neurotoxic, contributing to neuroprotection. The latter also results in the reduction of neuronal damage mediated by Aβ-mediated oxidative stress. These strong neuroprotective effects may bear relevance to pathogenesis and therapy of Alzheimer's disease (AD). This review focuses on melatonin as a therapeutic agent for Alzheimer's disease.

AB - Melatonin has a two different mechanism of action to prevent pro-amyloidogenic environment that leads to Alzheimer's amyloid β (Aβ) amyloidosis: (1) anti-amyloidogenic and (2) anti-oxidant properties. The former causes the reduction of the β-sheet-rich conformer which becomes aggregated and neurotoxic, contributing to neuroprotection. The latter also results in the reduction of neuronal damage mediated by Aβ-mediated oxidative stress. These strong neuroprotective effects may bear relevance to pathogenesis and therapy of Alzheimer's disease (AD). This review focuses on melatonin as a therapeutic agent for Alzheimer's disease.

KW - Alzheimer's disease

KW - Amyloid β

KW - Anti-amyloidogenic properties of melatonin

KW - Antioxidant properties of melatonin

KW - Melatonin

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JO - International Congress Series

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Alzheimer's disease and melatonin

Abstract

Keywords

ASJC Scopus subject areas

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