Alzheimer's disease and melatonin

Etsuro Matsubara; Mikio Shoji; Tetsuro Murakami; Takeshi Kawarabayashi; Koji Abe

doi:10.1016/S0531-5131(03)00019-0

Alzheimer's disease and melatonin

Etsuro Matsubara, Mikio Shoji, Tetsuro Murakami, Takeshi Kawarabayashi, Koji Abe

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

Melatonin has a two different mechanism of action to prevent pro-amyloidogenic environment that leads to Alzheimer's amyloid β (Aβ) amyloidosis: (1) anti-amyloidogenic and (2) anti-oxidant properties. The former causes the reduction of the β-sheet-rich conformer which becomes aggregated and neurotoxic, contributing to neuroprotection. The latter also results in the reduction of neuronal damage mediated by Aβ-mediated oxidative stress. These strong neuroprotective effects may bear relevance to pathogenesis and therapy of Alzheimer's disease (AD). This review focuses on melatonin as a therapeutic agent for Alzheimer's disease.

Original language	English
Pages (from-to)	395-398
Number of pages	4
Journal	International Congress Series
Volume	1252
Issue number	C
DOIs	https://doi.org/10.1016/S0531-5131(03)00019-0
Publication status	Published - Jun 1 2003

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Keywords

Alzheimer's disease
Amyloid β
Anti-amyloidogenic properties of melatonin
Antioxidant properties of melatonin
Melatonin

ASJC Scopus subject areas

Medicine(all)

Cite this

Matsubara, E., Shoji, M., Murakami, T., Kawarabayashi, T., & Abe, K. (2003). Alzheimer's disease and melatonin. International Congress Series, 1252(C), 395-398. https://doi.org/10.1016/S0531-5131(03)00019-0

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10.1016/S0531-5131(03)00019-0