Alternation in the coronary blood flow velocity pattern in patients with no reflow and reperfused acute myocardial infarction

Katsuomi Iwakura, Hiroshi Itoh, Shin Takiuchi, Yoshiaki Taniyama, Yoshiaki Nakatsuchi, Shinji Negoro, Yorihiko Higashino, Atsunori Okamura, Tohru Masuyama, Masatsugu Hori, Kenshi Fujii, Takazo Minamino

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Background: Experimental and clinical evidence indicates that myocardial ischemia often damages the coronary microvasculature ('no-reflow' phenomenon). In this study, we examined the effect of this phenomenon on the coronary blood flow velocity pattern in patients with reperfused acute myocardial infarction. Methods and Results: We measured coronary blood flow velocity after coronary angioplasty in 42 patients with acute myocardial infarction using a Doppler guidewire. Myocardial contrast echocardiography (MCE) was also performed before and after angioplasty. Thirty-one patients showed good contrasts reperfusion (MCE reflow), whereas the other 11 showed no reflow (MCE no reflow). Peak velocity and duration of systolic coronary flow were significantly less in patients with MCE no reflow than in those with MCE reflow (8±4 versus 17±10 cm/s and 207±79 versus 289±55 ms, respectively; P2, P

Original languageEnglish
Pages (from-to)1269-1275
Number of pages7
JournalCirculation
Volume94
Issue number6
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Blood Flow Velocity
Echocardiography
Myocardial Infarction
Angioplasty
No-Reflow Phenomenon
Myocardial Reperfusion
Microvessels
Myocardial Ischemia

Keywords

  • circulation
  • microcirculation
  • myocardial infarction
  • reperfusion
  • ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Iwakura, K., Itoh, H., Takiuchi, S., Taniyama, Y., Nakatsuchi, Y., Negoro, S., ... Minamino, T. (1996). Alternation in the coronary blood flow velocity pattern in patients with no reflow and reperfused acute myocardial infarction. Circulation, 94(6), 1269-1275.

Alternation in the coronary blood flow velocity pattern in patients with no reflow and reperfused acute myocardial infarction. / Iwakura, Katsuomi; Itoh, Hiroshi; Takiuchi, Shin; Taniyama, Yoshiaki; Nakatsuchi, Yoshiaki; Negoro, Shinji; Higashino, Yorihiko; Okamura, Atsunori; Masuyama, Tohru; Hori, Masatsugu; Fujii, Kenshi; Minamino, Takazo.

In: Circulation, Vol. 94, No. 6, 1996, p. 1269-1275.

Research output: Contribution to journalArticle

Iwakura, K, Itoh, H, Takiuchi, S, Taniyama, Y, Nakatsuchi, Y, Negoro, S, Higashino, Y, Okamura, A, Masuyama, T, Hori, M, Fujii, K & Minamino, T 1996, 'Alternation in the coronary blood flow velocity pattern in patients with no reflow and reperfused acute myocardial infarction', Circulation, vol. 94, no. 6, pp. 1269-1275.
Iwakura, Katsuomi ; Itoh, Hiroshi ; Takiuchi, Shin ; Taniyama, Yoshiaki ; Nakatsuchi, Yoshiaki ; Negoro, Shinji ; Higashino, Yorihiko ; Okamura, Atsunori ; Masuyama, Tohru ; Hori, Masatsugu ; Fujii, Kenshi ; Minamino, Takazo. / Alternation in the coronary blood flow velocity pattern in patients with no reflow and reperfused acute myocardial infarction. In: Circulation. 1996 ; Vol. 94, No. 6. pp. 1269-1275.
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AU - Negoro, Shinji

AU - Higashino, Yorihiko

AU - Okamura, Atsunori

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