Altered arterial stiffness in male-to-female transsexuals undergoing hormonal treatment

Sharula, Chebib Chekir, Yayoi Emi, Fujimi Arai, Yukako Kikuchi, Aiko Sasaki, Miwa Matsuda, Keiko Shimizu, Kazuhiro Tabuchi, Yasuhiko Kamada, Yuji Hiramatsu, Mikiya Nakatsuka

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Abstract

Aim: Male-to-female (MTF) transsexuals are treated with estrogen with and without progestin through a variety of routes. The aim of this study is to evaluate the arterial stiffness in MTF transsexuals undergoing hormonal treatment. Methods: We evaluated the arterial stiffness in 156 MTF transsexuals (22 untreated and 129 treated with estrogen only or plus progestin) using a volume-plethysmographic apparatus equipped with a multi-element applanation tonometry sensor. Results: MTF transsexuals treated with parenteral estrogen were significantly older than untreated MTF transsexuals. Hematocrit, uric acid and activated partial thromboplastin time in treated MTF transsexuals were significantly lower than in untreated MTF transsexuals. The level of high-density lipoprotein cholesterol in MTF transsexuals treated with oral estrogen was significantly higher than in untreated MTF transsexuals or those treated with parenteral estrogen with and without progestin. The systolic blood pressure in MTF transsexuals treated with estrogen only is significantly lower than that in untreated MTF transsexuals. The brachial-ankle pulse wave velocity was significantly decreased in MTF transsexuals treated with estrogen compared to that in untreated MTF transsexuals or in those treated with estrogen plus progestin. The carotid augmentation index in MTF transsexuals treated with oral estrogen was significantly lower than that in MTF transsexuals treated with parenteral estrogen or oral estrogen plus progestin. Conclusions: Estrogen treatment is likely to have some beneficial effects on lipid metabolism and vascular function in MTF transsexuals; however, progestin administered with estrogen may have adverse effects on arterial stiffness.

Original languageEnglish
Pages (from-to)932-940
Number of pages9
JournalJournal of Obstetrics and Gynaecology Research
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Keywords

  • Arterial stiffness
  • Estrogen
  • Progestin
  • Pulse wave velocity
  • Transsexual

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Sharula, Chekir, C., Emi, Y., Arai, F., Kikuchi, Y., Sasaki, A., Matsuda, M., Shimizu, K., Tabuchi, K., Kamada, Y., Hiramatsu, Y., & Nakatsuka, M. (2012). Altered arterial stiffness in male-to-female transsexuals undergoing hormonal treatment. Journal of Obstetrics and Gynaecology Research, 38(6), 932-940. https://doi.org/10.1111/j.1447-0756.2011.01815.x