Alterations of red blood cells’ polyamines during pregnancy and neonatal period

Yuji Hiramatsu, Katsuto Eguchi, Masaru Yonezawa, Ryoji Hayase, Kaoru Sekiba

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Red blood cell polyamines were measured using high-performance liquid chromatography. Spermidine and spermine continued to increase with pregnancy and retained a high level during 24–35 weeks of gestation, then decreased at term; putrescine, however, kept the low nonpregnant level during pregnancy and puerperium. At delivery, umbilical blood showed a significantly higher polyamine level than maternal blood (p < 0.005 or p < 0.001). In the neonatal period, each polyamine showed a slight increase on the 1st day after birth, then spermidine and spermine decreased day by day, but putrescine kept the same level. Alterations of polyamines seemed to have some relation to the erythropoiesis in bone marrow and rapid cell proliferations.

Original languageEnglish
Pages (from-to)136-144
Number of pages9
Issue number3-4
Publication statusPublished - 1981


  • Delivery
  • Neonatal period
  • Polyamine
  • Pregnancy
  • Puerperium
  • Red blood cell

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology


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