Alterations of colonizing features of skin bacteria and influence on therapeutic responses in atopic dermatitis

Keiji Iwatsuki, Takashi Oono, Osamu Yamasaki, Hisanori Akiyama

Research output: Contribution to journalArticle

Abstract

Colonization of Staphylococcus aureus is one of the important aggravating factors in atopic dermatitis. As far as we live in daily life, however, it is impossible to eradicate all bacteria from the skin and keep it aseptic for long. Neither antimicrobial nor antiseptic treatment is promising for eradication of colonizing S. aureus in the horny layers covered with biofilm. Nevertheless, antimicrobial and antiseptic treatments including popidone iodine have been used for atopic dermatitis, with evidence of the decrease of bacterial counts on the skin and some clinical improvements after the treatments. These results, however, should be interpreted and reevaluated carefully. We believe that control of overgrowth of S. aureus in atopic dermatitis should be achieved by proper skin cares and standard treatments for dermatitis, in consideration of the effect of normal bacterial flora, barrier functions of normal horny layers, and expression of antimicrobial peptides.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalSkin Research
Volume4
Issue numberSUPPL. 5
Publication statusPublished - Oct 2005

Fingerprint

Atopic Dermatitis
Bacteria
Staphylococcus aureus
Skin
Local Anti-Infective Agents
Skin Care
Bacterial Load
Dermatitis
Therapeutics
Standard of Care
Biofilms
Iodine
Peptides

Keywords

  • Antimicrobial
  • Antiseptic
  • Atopic dermatitis
  • Biofilm
  • Colonization
  • S. aureus

ASJC Scopus subject areas

  • Dermatology

Cite this

Alterations of colonizing features of skin bacteria and influence on therapeutic responses in atopic dermatitis. / Iwatsuki, Keiji; Oono, Takashi; Yamasaki, Osamu; Akiyama, Hisanori.

In: Skin Research, Vol. 4, No. SUPPL. 5, 10.2005, p. 94-98.

Research output: Contribution to journalArticle

@article{19fc66e129504bccbb2b14e975dd9f9d,
title = "Alterations of colonizing features of skin bacteria and influence on therapeutic responses in atopic dermatitis",
abstract = "Colonization of Staphylococcus aureus is one of the important aggravating factors in atopic dermatitis. As far as we live in daily life, however, it is impossible to eradicate all bacteria from the skin and keep it aseptic for long. Neither antimicrobial nor antiseptic treatment is promising for eradication of colonizing S. aureus in the horny layers covered with biofilm. Nevertheless, antimicrobial and antiseptic treatments including popidone iodine have been used for atopic dermatitis, with evidence of the decrease of bacterial counts on the skin and some clinical improvements after the treatments. These results, however, should be interpreted and reevaluated carefully. We believe that control of overgrowth of S. aureus in atopic dermatitis should be achieved by proper skin cares and standard treatments for dermatitis, in consideration of the effect of normal bacterial flora, barrier functions of normal horny layers, and expression of antimicrobial peptides.",
keywords = "Antimicrobial, Antiseptic, Atopic dermatitis, Biofilm, Colonization, S. aureus",
author = "Keiji Iwatsuki and Takashi Oono and Osamu Yamasaki and Hisanori Akiyama",
year = "2005",
month = "10",
language = "English",
volume = "4",
pages = "94--98",
journal = "Skin Research",
issn = "0018-1390",
publisher = "Osaka University",
number = "SUPPL. 5",

}

TY - JOUR

T1 - Alterations of colonizing features of skin bacteria and influence on therapeutic responses in atopic dermatitis

AU - Iwatsuki, Keiji

AU - Oono, Takashi

AU - Yamasaki, Osamu

AU - Akiyama, Hisanori

PY - 2005/10

Y1 - 2005/10

N2 - Colonization of Staphylococcus aureus is one of the important aggravating factors in atopic dermatitis. As far as we live in daily life, however, it is impossible to eradicate all bacteria from the skin and keep it aseptic for long. Neither antimicrobial nor antiseptic treatment is promising for eradication of colonizing S. aureus in the horny layers covered with biofilm. Nevertheless, antimicrobial and antiseptic treatments including popidone iodine have been used for atopic dermatitis, with evidence of the decrease of bacterial counts on the skin and some clinical improvements after the treatments. These results, however, should be interpreted and reevaluated carefully. We believe that control of overgrowth of S. aureus in atopic dermatitis should be achieved by proper skin cares and standard treatments for dermatitis, in consideration of the effect of normal bacterial flora, barrier functions of normal horny layers, and expression of antimicrobial peptides.

AB - Colonization of Staphylococcus aureus is one of the important aggravating factors in atopic dermatitis. As far as we live in daily life, however, it is impossible to eradicate all bacteria from the skin and keep it aseptic for long. Neither antimicrobial nor antiseptic treatment is promising for eradication of colonizing S. aureus in the horny layers covered with biofilm. Nevertheless, antimicrobial and antiseptic treatments including popidone iodine have been used for atopic dermatitis, with evidence of the decrease of bacterial counts on the skin and some clinical improvements after the treatments. These results, however, should be interpreted and reevaluated carefully. We believe that control of overgrowth of S. aureus in atopic dermatitis should be achieved by proper skin cares and standard treatments for dermatitis, in consideration of the effect of normal bacterial flora, barrier functions of normal horny layers, and expression of antimicrobial peptides.

KW - Antimicrobial

KW - Antiseptic

KW - Atopic dermatitis

KW - Biofilm

KW - Colonization

KW - S. aureus

UR - http://www.scopus.com/inward/record.url?scp=28844438424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28844438424&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 94

EP - 98

JO - Skin Research

JF - Skin Research

SN - 0018-1390

IS - SUPPL. 5

ER -