Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice

Hiroshi Ueno, Kazuki Fujii, Keizo Takao, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yousuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Research output: Contribution to journalArticle

Abstract

Aging is associated with decline in cognitive function, but the underlying mechanisms have not been elucidated. Normal activity of pyramidal cells and parvalbumin-expressing interneurons (PV neurons) is essential for cognitive function. PV neurons participate in the regulation of pyramidal-cell firing. Abnormal function of PV neurons may occur with aging. We analyzed the density and the percentage of PV neurons surrounded by perineuronal nets (PNNs) in the entire cortex of adult (3-month-old) and aged (24-month-old) mice. PNNs are extracellular matrix molecules that cover PV neurons and control synaptic plasticity. PV-neuron density decreased in some cortical areas of aged compared to adult mice. In particular, in the retrosplenial granular cortex (RSG) of aged mice, pyramidal cells expressed PV protein at high levels. This study suggests that the RSG of aged mice is in an abnormal activated state. RSG function abnormality may be part of the cognitive decline mechanism.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalMolecular and Cellular Neuroscience
Volume95
DOIs
Publication statusPublished - Mar 1 2019

Fingerprint

Parvalbumins
Interneurons
Cerebral Cortex
Pyramidal Cells
Cognition
Neuronal Plasticity
Extracellular Matrix
Neurons
Proteins

Keywords

  • Aging
  • Cerebral cortex
  • Mouse
  • Parvalbumin
  • Perineuronal nets
  • Retrosplenial cortex

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice. / Ueno, Hiroshi; Fujii, Kazuki; Takao, Keizo; Suemitsu, Shunsuke; Murakami, Shinji; Kitamura, Naoya; Wani, Kenta; Matsumoto, Yousuke; Okamoto, Motoi; Ishihara, Takeshi.

In: Molecular and Cellular Neuroscience, Vol. 95, 01.03.2019, p. 31-42.

Research output: Contribution to journalArticle

Ueno, H, Fujii, K, Takao, K, Suemitsu, S, Murakami, S, Kitamura, N, Wani, K, Matsumoto, Y, Okamoto, M & Ishihara, T 2019, 'Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice', Molecular and Cellular Neuroscience, vol. 95, pp. 31-42. https://doi.org/10.1016/j.mcn.2018.12.008
Ueno, Hiroshi ; Fujii, Kazuki ; Takao, Keizo ; Suemitsu, Shunsuke ; Murakami, Shinji ; Kitamura, Naoya ; Wani, Kenta ; Matsumoto, Yousuke ; Okamoto, Motoi ; Ishihara, Takeshi. / Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice. In: Molecular and Cellular Neuroscience. 2019 ; Vol. 95. pp. 31-42.
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