Alteration of chloral hydrate metabolism in rats with carbon tetrachloride-induced liver damage

Kawamoto Toshihiro, Hobara Tatsuya, Kobayashi Haruo, Iwamoto Susumu, Sakai Tsunemi, Ogino Keiki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The metabolism of chloral hydrate (CH) was investigated in the isolated perfused rat liver system. The experiments were performed on rats that were administered carbon tetrachloride (CCl4) subcutaneously for 15 weeks to induce chronic liver damage and on untreated rats. Clearance of CH from the perfusion system was lower in damaged liver than in control liver. In both groups, 50-70% of the added CH was excreted into perfusate as trichloroethanol (TCE) and trichloroacetic acid (TCA) within 120 min. The TCE/TCA ratio was 1:1.3 in the control group compared to 2:1 in the damaged liver group. The findings suggest that CH metabolism in the liver is affected by chronic damage.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalToxicology Letters
Volume37
Issue number3
DOIs
Publication statusPublished - Aug 1987

Keywords

  • Chloral hydrate
  • carbon tetrachloride
  • drug metabolism
  • liver
  • perfusion
  • trichloroacetic acid
  • trichloroethanol

ASJC Scopus subject areas

  • Toxicology

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