Alteration in the composition of cholesteryl glucosides and other lipids in Helicobacter pylori undergoing morphological change from spiral to coccoid form

Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In this analysis of membrane lipid compositions in Helicobacter pylori, the membrane lipid profiles drastically changed during coccoid formation: cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside levels increased, cholesteryl-α-D-glucopyranoside and phosphatidyl ethanolamine decreased, and a coordinated increase in cardiolipin and decrease in phosphatidyl glycerol were observed. Cholesteryl-6-O-phosphatidyl-α-D-glucopyranoside was hardly detected in the spiral forms in the logarithmic phase, but subsequently increased throughout the coccoid conversion. These results suggest that environmental stresses induce the expression of certain regulatory systems for lipid metabolism in H. pylori, and that the resulting alterations in lipid composition play an important role in inducing the coccoid conversion.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalFEMS Microbiology Letters
Volume237
Issue number2
DOIs
Publication statusPublished - Aug 15 2004

Keywords

  • Cholesteryl glucosides
  • Coccoid forms
  • Helicobacter pylori

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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