Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development

Yasuto Takeuchi, Fusao Ikeda, Toshiya Osawa, Yasuyuki Araki, Kouichi Takaguchi, Youichi Morimoto, Noriaki Hashimoto, Kousaku Sakaguchi, Tatsuro Sakata, Masaharu Ando, Yasuhiro Makino, Shuji Matsumura, Hiroki Takayama, Hiroyuki Seki, Shintarou Nanba, Yuki Moritou, Tetsuya Yasunaka, Hideki Ohnishi, Akinobu Takaki, Kazuhiro NousoYoshiaki Iwasaki, Kazuhide Yamamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

AIM: To investigate factors that accurately predict hepatocellular carcinoma (HCC) development after antiviral therapy in chronic hepatitis C (CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein (AFP) to predict HCC development after interferon (IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response (SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5ng/mL before therapy and in non-SVR patients showing AFP ≥ 5ng/mL before and 1year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5ng/mL before therapy and no decrease in AFP to < 5ng/mL 1year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5ng/ mL before therapy and decreased AFP (P = 0.043). AFP ≥ 5ng/mL before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase (ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5ng/mL before therapy than in those showing AFP ≥ 5ng/mL. CONCLUSION: The criteria of AFP < 5ng/mL before and 1year after IFN therapy is a benefical predictor for HCC development in CHC patients.

Original languageEnglish
Pages (from-to)2220-2228
Number of pages9
JournalWorld Journal of Hepatology
Volume7
Issue number19
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Alpha-fetoprotein
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Interferon

ASJC Scopus subject areas

  • Hepatology

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    Takeuchi, Y., Ikeda, F., Osawa, T., Araki, Y., Takaguchi, K., Morimoto, Y., Hashimoto, N., Sakaguchi, K., Sakata, T., Ando, M., Makino, Y., Matsumura, S., Takayama, H., Seki, H., Nanba, S., Moritou, Y., Yasunaka, T., Ohnishi, H., Takaki, A., ... Yamamoto, K. (2015). Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development. World Journal of Hepatology, 7(19), 2220-2228. https://doi.org/10.4254/wjh.v7.i19.2220