Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection

N. Fujii, K. Takenaka, A. Hiraki, Y. Maeda, K. Ikeda, K. Shinagawa, A. Ashiba, M. Munemasa, K. Sunami, Y. Hiramatsu, F. Ishimaru, K. Niiya, T. Yoshino, M. Harada

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24 Citations (Scopus)

Abstract

The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

Original languageEnglish
Pages (from-to)805-808
Number of pages4
JournalBone Marrow Transplantation
Volume26
Issue number7
DOIs
Publication statusPublished - 2000

Keywords

  • Allogeneic peripheral blood stem cell transplantation
  • Chronic active Epstein-Barr virus infection
  • EBV-specific CTL
  • Myeloablative conditioning regimen

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Fujii, N., Takenaka, K., Hiraki, A., Maeda, Y., Ikeda, K., Shinagawa, K., Ashiba, A., Munemasa, M., Sunami, K., Hiramatsu, Y., Ishimaru, F., Niiya, K., Yoshino, T., & Harada, M. (2000). Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection. Bone Marrow Transplantation, 26(7), 805-808. https://doi.org/10.1038/sj.bmt.1702600