Allele frequencies of single nucleotide polymorphisms in the second exon of the myoglobin gene among the Japanese

Tomoyo Takata, Satoru Miyaishi, Yuji Yamamoto, Sachiyo Inagaki, Kei Yoshitome, Takaki Ishikawa, Hideo Ishizu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The difference in the allele frequencies of two single nucleotide polymorphisms (SNPs) in the second exon of the myoglobin gene between Japanese and other populations is reported. These SNPs are the substitutions of (A79G) and (T109C), and they were investigated by a single polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis followed by direct sequencing. The substitutions were always linked and two alleles were found in the samples used: the A-T allele with no substitution at positions (79A) and (109T) and the G-C allele with substitutions of (79G) and (109C). The frequencies of these alleles were 0.755 and 0.245, respectively, and they were found to be in Hardy-Weinberg equilibrium. The distribution of alleles in the Japanese population was significantly different from that reported among whites, blacks, and Hispanics (p < 0.0001).

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalHuman Biology
Volume74
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Japanese population
  • Myoglobin
  • Single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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