All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan

R. Ohno, K. Ohnishi, A. Takeshita, M. Tanimoto, H. Murakami, A. Kanamaru, N. Asou, T. Kobayashi, K. Kuriyama, E. Ohmoto, H. Sakamaki, K. Tsubaki, A. Hiraoka, O. Yamada, H. Oh, S. Furusawa, S. Matsuda, T. Naoe

Research output: Contribution to journalArticle

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Abstract

We have conducted four prospective multicenter studies for acute promyelocytic leukemia (APL) using oral 45 mg/m2 all-trans retinoic acid (ATRA) daily. The first three studies were for relapsed/refractory APL, and the fourth study for newly diagnosed APL. In the first study with ATRA alone, 18 (82%) of 22 evaluable patients achieved complete remission (CR). Initial peripheral leukemia cell counts were significantly less in the CR cases (p

Original languageEnglish
JournalLeukemia
Volume8
Issue numberSUPPL. 3
Publication statusPublished - 1994
Externally publishedYes

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Acute Promyelocytic Leukemia
Tretinoin
Japan
Multicenter Studies
Leukemia
Therapeutics
Cell Count
Prospective Studies

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Ohno, R., Ohnishi, K., Takeshita, A., Tanimoto, M., Murakami, H., Kanamaru, A., ... Naoe, T. (1994). All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan. Leukemia, 8(SUPPL. 3).

All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan. / Ohno, R.; Ohnishi, K.; Takeshita, A.; Tanimoto, M.; Murakami, H.; Kanamaru, A.; Asou, N.; Kobayashi, T.; Kuriyama, K.; Ohmoto, E.; Sakamaki, H.; Tsubaki, K.; Hiraoka, A.; Yamada, O.; Oh, H.; Furusawa, S.; Matsuda, S.; Naoe, T.

In: Leukemia, Vol. 8, No. SUPPL. 3, 1994.

Research output: Contribution to journalArticle

Ohno, R, Ohnishi, K, Takeshita, A, Tanimoto, M, Murakami, H, Kanamaru, A, Asou, N, Kobayashi, T, Kuriyama, K, Ohmoto, E, Sakamaki, H, Tsubaki, K, Hiraoka, A, Yamada, O, Oh, H, Furusawa, S, Matsuda, S & Naoe, T 1994, 'All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan', Leukemia, vol. 8, no. SUPPL. 3.
Ohno R, Ohnishi K, Takeshita A, Tanimoto M, Murakami H, Kanamaru A et al. All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan. Leukemia. 1994;8(SUPPL. 3).
Ohno, R. ; Ohnishi, K. ; Takeshita, A. ; Tanimoto, M. ; Murakami, H. ; Kanamaru, A. ; Asou, N. ; Kobayashi, T. ; Kuriyama, K. ; Ohmoto, E. ; Sakamaki, H. ; Tsubaki, K. ; Hiraoka, A. ; Yamada, O. ; Oh, H. ; Furusawa, S. ; Matsuda, S. ; Naoe, T. / All-trans retinoic acid therapy in relapsed/refractory or newly diagnosed acute promyelocytic leukemia (APL) in Japan. In: Leukemia. 1994 ; Vol. 8, No. SUPPL. 3.
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AU - Ohno, R.

AU - Ohnishi, K.

AU - Takeshita, A.

AU - Tanimoto, M.

AU - Murakami, H.

AU - Kanamaru, A.

AU - Asou, N.

AU - Kobayashi, T.

AU - Kuriyama, K.

AU - Ohmoto, E.

AU - Sakamaki, H.

AU - Tsubaki, K.

AU - Hiraoka, A.

AU - Yamada, O.

AU - Oh, H.

AU - Furusawa, S.

AU - Matsuda, S.

AU - Naoe, T.

PY - 1994

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