Alkylation methodology for the synthesis of 1,4-disilacyclohexanes using α,α'-dilithiated silanes

Masaki Shimizu, Masayuki Iwakubo, Yasushi Nishihara, Tamejiro Hiyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The double alkylation of bis[2-(2-lithio-1,3-dithian)-yl]diorganosilane with bis(bromomethyl)diorganosilanes proceeds smoothly in good yields in a mixture of THF-hexamethylphosphoric trianide (HMPA) or THF-1,1,3,3- tetramethylurea (TMU) to give 1,4-disilacyclohexanes whose conformation was shown to be a twist-boat on the basis of X-ray analysis.

Original languageEnglish
Pages (from-to)3197-3200
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number20
DOIs
Publication statusPublished - May 14 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Alkylation methodology for the synthesis of 1,4-disilacyclohexanes using α,α'-dilithiated silanes'. Together they form a unique fingerprint.

  • Cite this